Life sciences · Phase 2 Trial
ClinicalTrials.gov · September 18, 2026
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Phase 2 Trial.
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Registry record from ClinicalTrials.gov (NCT05801133). This is a study registration, not published results. Lead sponsor: Hubei Cancer Hospital. Recruitment status: COMPLETED. Phase: PHASE2. Study type: INTERVENTIONAL. Enrollment: 41 participants (ACTUAL). Conditions: Lung Cancer. Interventions: DRUG: Pirfenidone. Primary outcome measures: Incidence rate of radiation pneumonia ≥ grade 2 (1 month, 3 month, 6 month) , up to 6 month. Brief summary: Patients with advanced lung cancer who have previously received immunocheckpoint inhibitor therapy, undergone chest radiation therapy again have developed radiation induced lung injury. Pirfenidone has anti-inflammatory and anti fibrosis effects. This study is intended to evaluate the effectiveness of pirfenidone combined with radiotherapy in the prevention of radiation pneumonitis.