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Life sciences · Interventional Study
ClinicalTrials.gov · October 23, 2026
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Interventional Study.
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Registry record from ClinicalTrials.gov (NCT05456035). This is a study registration, not published results. Lead sponsor: Vanderbilt University. Recruitment status: RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 82 participants (ESTIMATED). Conditions: Depression. Interventions: BEHAVIORAL: Cognitive behavioral therapy plus social cognitive training (CBTSCT). Primary outcome measures: Faux Pas Recognition Test , after 12 weeks; Children's Depression Rating Scale-Revised , after 12 weeks. Brief summary: Depression in youth is a serious public health concern for which more personalized treatments are needed. This randomized controlled trial will test the effect of an intervention aimed at enhancing social cognitive capacities (e.g., ability to take another's perspective), thereby making treatment of depression in youth more efficient and effective. Participants in the R33 (N=82) will be youth between ages 13- through 17-years-old currently experiencing depression. Youth will be randomized to either an enhanced CBT intervention that teaches social cognitive skills, particularly social perspective taking and theory of mind (CBTSCT) as compared to CBT only. The primary target is improvement in both social cognitive skills and depressive symptoms at post-treatment and at a 6-month follow-up.