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Life sciences · Interventional Study
ClinicalTrials.gov · October 16, 2026
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Interventional Study.
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Registry record from ClinicalTrials.gov (NCT07644806). This is a study registration, not published results. Lead sponsor: Old Dominion University. Recruitment status: RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 40 participants (ESTIMATED). Conditions: Heart Failure With Reduced Ejection Fraction (HFrEF). Interventions: OTHER: Extra-virgin olive oil. Primary outcome measures: Change in 24-hour dietary recall monounsaturated fatty acids (MUFA) , At baseline, and 12-week; Change in dietary compliance (plasma monounsaturated fatty acids) , At baseline and 12-week. Brief summary: The OLEA-HF study aims to explore whether daily supplementation of extra-virgin olive oil (EVOO) for 12 weeks during participation in a cardiac rehabilitation program (standard of care) is feasible in patients with heart failure with reduced ejection fraction (HFrEF). The investigators will also determine the effects of EVOO on functional capacity and quality of life.