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Life sciences · Observational Study
ClinicalTrials.gov · September 23, 2026
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Observational Study.
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Registry record from ClinicalTrials.gov (NCT07837349). This is a study registration, not published results. Lead sponsor: French Cardiology Society. Recruitment status: NOT_YET_RECRUITING. Study type: OBSERVATIONAL. Enrollment: 1000 participants (ESTIMATED). Conditions: NT-pro-BNP, NT-proBNP, CHF, Chronic Heart Failure. Primary outcome measures: Sensitivity of the combined EPOF questionnaire and natriuretic peptide strategy for detecting chronic heart failure , Baseline. Brief summary: This observational study aims to evaluate whether measuring NT-proBNP (or BNP), either on its own or alongside the EPOF questionnaire, can improve the early detection of chronic heart failure (CHF) in adults aged 40 years or over who are referred for an outpatient cardiology evaluation and have no known or suspected CHF. The study will address the following questions: Does systematic NT-proBNP (or BNP) testing help to identify previously unrecognised CHF? Does combining NT-proBNP (or BNP) with the EPOF questionnaire enhance diagnostic accuracy compared with using each tool alone? Participants will attend their routine cardiology consultation, complete the EPOF questionnaire and undergo NT-proBNP (or BNP) testing as part of the clinical assessment. They will also allow the collection of relevant medical data. The diagnostic performance of these tools will then be compared with the final diagnosis made by the outpatient cardiologist. The study focuses on a population referred from primary care with increased cardiovascular risk. The early use of simple, accessible tools could reduce diagnostic delays, improve referral appropriateness and facilitate the earlier detection of CHF in general practice.