Life sciences · Observational Study
ClinicalTrials.gov · October 14, 2026
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Observational Study.
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Registry record from ClinicalTrials.gov (NCT03532477). This is a study registration, not published results. Lead sponsor: Norwegian University of Science and Technology. Recruitment status: RECRUITING. Study type: OBSERVATIONAL. Enrollment: 12 participants (ESTIMATED). Conditions: Obesity, Morbid. Interventions: DRUG: Venlafaxine. Primary outcome measures: Venlafaxine concentration in blood serum (area under curve (AUC)) , From baseline to 1 year postoperatively. Brief summary: Changes to gastric pH, gastric emptying time, gastrointestinal transit-time or the pre-systemic metabolizing effect of enzymes secreted in the mucosa may all alter the pharmacokinetics of medicines. These factors are potentially influenced by bariatric surgery. Little is so far known about how gastric bypass and sleeve gastrectomy impacts the biological availability of medication. In this study the pharmacokinetic effects of bariatric surgery on venlafaxine are investigated.