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Diabetes, Gestational / Gestational Diabetes Mellitus / Genetic Predisposition to Disease · Genetic association study
Annals of Medicine · July 17, 2026
Reinforces what was already believed, rather than introducing something new.
This case-control study of 836 Thai pregnant women identifies 17 SNPs across six genes (TCF7L2, NEDD1, CMIP, CDKAL1, GCK, GCKR) associated with GDM susceptibility after adjustment for maternal age and pre-pregnancy BMI. Haplotype analysis reveals both protective and risk-conferring genetic combinations, supporting the role of metabolic gene variants in GDM pathogenesis within the Thai population.
Case-control study. 152 pregnant women with GDM and 684 pregnant women with normal glucose tolerance undergoing antenatal examination. n = 836. Siriraj Hospital, Bangkok, Thailand.
The TCF7L2 rs12243326-rs12255372 CA haplotype was associated with decreased GDM risk (OR = 0.44, 95% CI: 0.23-0.81) The NEDD1 rs249579-rs249585-rs4762339 GGT haplotype was associated with increased GDM risk (OR = 1.40, 95% CI: 1.08-1.82) 17 SNPs across TCF7L2, NEDD1, CMIP, CDKAL1, GCKR, and GCK were significantly associated with GDM risk after adjustment
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These genetic associations confirm that metabolic gene variants contribute to GDM susceptibility in Thai women, though single-center recruitment and population specificity limit broader generalizability. The findings support the multigenic nature of GDM but do not yet inform clinical screening or management decisions.
Case-control genetic association study with 836 participants confirms known candidate genes contribute to GDM risk in Thai population with haplotype-specific effects.
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Quoted from the source exactly as published.
These genetic associations confirm that metabolic gene variants contribute to GDM susceptibility in Thai women, though single-center recruitment and population specificity limit broader generalizability. The findings support the multigenic nature of GDM but do not yet inform clinical screening or management decisions.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
Background. Gestational diabetes mellitus (GDM) has a high global prevalence and arises from complex interactions between genetic predisposition and environmental factors. GDM is associated with metabolic disturbances and chronic low-grade inflammation, both of which contribute to its pathogenesis. This study aimed to investigate the association between GDM and 135 single-nucleotide polymorphisms (SNPs) across 20 genes related to metabolic traits.Methods. In this case-control study, 152 pregnant women with GDM and 684 pregnant women with normal glucose tolerance (NGT) who underwent antenatal examination at Siriraj Hospital, Bangkok, were enrolled. Clinical data and blood samples were collected from all participants. Genomic DNA was isolated and subjected to whole-genome sequencing using the DNBSEQ-T7RS high-throughput sequencing platform. Genotype analyses were performed using R software, and haplotype analyses were conducted using the online SNPStats software.Results. After adjusting for maternal age and pre-pregnancy body mass index, polymorphisms in TCF7L2 (rs34872471, rs7901695, rs4506565, rs7903146, rs12243326, and rs12255372), NEDD1 (rs10431408, rs11830756, rs249579, rs249585, and rs4762339), CMIP (rs2306115 and rs201681534), CDKAL1 (rs4710942), GCKR (rs2293572 and rs2293571), and GCK (rs5883890) were significantly associated with the risk of GDM. Haplotype analysis demonstrated that the TCF7L2 rs12243326-rs12255372 CA haplotype was associated with a decreased risk of GDM (OR = 0.44, 95% CI: 0.23-0.81), while the NEDD1 rs249579-rs249585-rs4762339 GGT haplotype was associated with an increased risk of GDM (OR = 1.40, 95% CI: 1.08-1.82).Conclusions. These findings suggest that genetic variations in TCF7L2, NEDD1, CMIP, CDKAL1, GCK, and GCKR contribute to GDM susceptibility in the Thai population.
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