Life sciences · Journal article
Global Health Research and Policy · June 22, 2026
A consensus or society position rather than new primary data.
This is a perspective article proposing an equity-centered adaptation of the PEDALs implementation science model to reduce health disparities in global health systems. It outlines methodological and design considerations—including hybrid designs, participatory methods, and embedded research—to embed equity across problem identification, evidence appraisal, determinant analysis, action design, long-term measurement, and scale-up, but presents no primary empirical evidence or formal evidence synthesis.
Journal article. Implementation science and practice efforts in global health, particularly in low- and middle-income countries; marginalized populations affected by health disparities..
The 'know-do gap' between evidence-based practice development and routine use in health systems remains a barrier to global health equity. PEDALs model stages can embed equity considerations: identifying root causes of inequity (P), using mixed evidence while adapting or de-implementing (E), engaging marginalized voices (D), co-designing strategies (A), measuring outcomes through an equity lens (L), and attending to scalability and learning (s). Methodological approaches supporting equity-centered implementation include hybrid designs, embedded and workflow-based research, and rapid participatory methods, particularly for low- and middle-income countries.
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This framework is intended to guide researchers and practitioners designing implementation studies and health system interventions to center equity and reduce disparities. Adoption requires deliberate methodological choice and stakeholder engagement at each stage of implementation.
A methodological framework and expert perspective proposing equity-centered design considerations for implementation science, without empirical trial data or formal evidence synthesis.
This framework is intended to guide researchers and practitioners designing implementation studies and health system interventions to center equity and reduce disparities. Adoption requires deliberate methodological choice and stakeholder engagement at each stage of implementation.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
What is missing. This record has no reported figures. That is a gap in the analysis, not a judgement about the study.
The persistent "know-do gap"-the lag between the development of evidence-based practices (EBPs) and their routine use in health systems-remains a barrier to achieving global health equity. Implementation science offers a pathway to bridge this gap, but without an explicit equity focus, it risks reinforcing existing disparities. In this perspective, we propose an equity-centered adaptation of the PEDALs model (Problem, Evidence-based practice, Determinants, Action, Long-term use, and scale) to guide more just and context-sensitive implementation efforts in global health. We describe how each stage of PEDALs can be used to embed equity considerations in implementation research and practice. These include identifying root causes of inequity-linked health problems (P), using both scientific and practice-based evidence while adapting or de-implementing interventions (E), engaging marginalized voices when analyzing barriers and facilitators (D), co-designing contextually grounded implementation strategies (A), and measuring long-term implementation outcomes through an equity lens (L), including attention to scalability, iterative learning, and proper design and methods (s). We highlight methodological considerations-such as hybrid designs, embedded and workflow-based research, and rapid and participatory methods-that support timely, relevant, and equitable implementation. Our model builds on the concept of "radical incrementalism" to emphasize steady, equity-driven change that is responsive to diverse settings, especially in low- and middle-income countries. This modified PEDALs-based approach offers a practical structure for design and methodological considerations in advancing equity-centered implementation science.
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