Application of the Phoenix Sepsis Score / Infection / Sepsis · Observational Study

Early Sepsis Recognition Tool

ClinicalTrials.gov · August 7, 2026

Preliminary Why this matters to you Expert discussion

Early or partial results. Treat as a signal, not a conclusion.

AI Summary

This is a prospective observational registry study currently recruiting to validate the Phoenix Sepsis Score and derive a pediatric sepsis recognition tool (SORT) across Asian pediatric critical care networks. No results have been posted; the study is in active enrollment with a planned duration of 2 years.

What was studied

Observational. Infection, Sepsis; to 18 Years. Intervention: Retrospective Cohort; Prospective Cohort. n = 40,000. 19 sites across 9 countries.

Key findings

Safety

Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.

Who this may help

This study aims to validate and improve sepsis recognition in pediatric populations across diverse Asian healthcare settings. Results, when available, may guide adoption of standardized sepsis criteria in resource-varied regions.

Plain-language summary

This is an active observational registry study with no posted results; it describes planned enrollment and outcome measures for sepsis recognition tool validation across Asian pediatric sites.

Study design

As stated by the source record.

MethodsCohort model. Other time perspective. Primary outcome measures: Performance of Phoenix Sepsis Score in Pediatric Acute and Critical Care Medicine in Asia Network (PACCMAN) sites in Asia (assessed at 2 years); Performance of Phoenix Sepsis Score in Pediatric Acute and Critical Care Medicine in Asia Network (PACCMAN) sites in Asia (assessed at 2 years); Derivation of an early recognition tool called Sepsis Optimal Recognition Toolkit in children (SORT) (assessed at 2 years)

DesignObservational

PopulationInfection, Sepsis; to 18 Years

Sample size40,000

InterventionRetrospective Cohort; Prospective Cohort

Setting19 sites across 9 countries

Reported figures

Quoted from the source exactly as published.

Estimated enrollment40000

Primary outcome measure 1Performance of Phoenix Sepsis Score in PACCMAN sites in Asia, 2 years

Primary outcome measure 2Derivation of Sepsis Optimal Recognition Toolkit in children (SORT), 2 years

Clinical bottom line

Caveats

No results posted; this is a registry record only, not a published trial report.
Study is currently recruiting; data collection and analysis incomplete.
Implementation science and barriers/facilitators to adoption are secondary objectives; primary clinical performance results are pending.
Geographic specificity to Asia; generalizability to other regions unknown.

Evidence assessment

Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.

Study design

moderate

Observational design clearly stated; prospective data collection implied by recruitment status.

Directness

strong

Directly evaluates performance of Phoenix Sepsis Score in pediatric acute care across Asia.

Consistency

insufficient

Single study; no comparative data or prior validation results reported in registry record.

Risk of bias

insufficient

Registry record does not describe blinding, allocation concealment, or other bias mitigation strategies.

Sample adequacy

moderate

Estimated 40,000 participants across multiple PACCMAN sites; large sample planned.

What is missing. This record has no key findings. That is a gap in the analysis, not a judgement about the study.

Source abstract

Registry record from ClinicalTrials.gov (NCT07397689). This is a study registration, not published results. Lead sponsor: KK Women's and Children's Hospital. Recruitment status: RECRUITING. Study type: OBSERVATIONAL. Enrollment: 40000 participants (ESTIMATED). Conditions: Infection, Sepsis. Interventions: OTHER: Application of the Phoenix Sepsis Score. Primary outcome measures: Performance of Phoenix Sepsis Score in Pediatric Acute and Critical Care Medicine in Asia Network (PACCMAN) sites in Asia , 2 years; Performance of Phoenix Sepsis Score in Pediatric Acute and Critical Care Medicine in Asia Network (PACCMAN) sites in Asia , 2 years; Derivation of an early recognition tool called Sepsis Optimal Recognition Toolkit in children (SORT) , 2 years. Brief summary: This study seeks to develop early recognition tools specially designed for children meeting the Phoenix definition and explore implementation science aspects by investigating facilitators and barriers to adopting Phoenix sepsis criteria in clinical practice. This addresses the critical need for systemic, evidence-based approaches to paediatric sepsis identification across diverse healthcare settings in Asia.

Follow from this

Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.

Application of the Phoenix Sepsis ScoreInfectionNCT07397689KK Women's and Children's HospitalSepsis