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Life sciences · Preprint
arXiv · October 5, 2026
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Long-running agents repeatedly call an LLM while retaining most of their document window, evicting old documents, and appending new ones. These rolling updates break exact prefix caching and motivate non-prefix KV-cache reuse with selective recomputation. We show that persistent KV-cache reuse with selective recomputation can be history-dependent: in our rolling-agent workload, an unchanged prompt can produce different answers depending on the requests processed before it. At a matched 5% recomputation budget, document-aligned recomputation reduces answer variation across request orders from 69.0% with CacheBlend's token top-$k$ policy to 26.1%. When each prompt is evaluated after a different sequence of preceding requests, document-aligned recomputation improves fidelity to full prefill by 34.5-52.5 percentage points over token top-$k$, while both policies achieve approximately 5.7$\times$ median TTFT speedup. Our ablation study shows that, in our rolling-agent workload, contiguity is the main factor associated with robust selective recomputation.