Loading
Gastric Cancer Management and Outcomes · Journal article
BMC Cancer · August 15, 2026
Encouraging direction, but not yet definitive.
In a single-centre retrospective cohort of 557 gastric cancer patients undergoing radical gastrectomy, the combination of overweight/obesity with metabolic syndrome was associated with worse overall survival compared to normal weight without MetS (P = 0.033), but the additional survival decrement attributable to MetS beyond overweight/obesity alone was not statistically significant (P = 0.163). Postoperative complication rates showed a U-shaped relationship with BMI, with optimal risk stratification at BMI ≥ 22.82 kg/m² in combination with metabolic abnormalities.
Retrospective cohort study with propensity-score-based baseline matching. Five hundred fifty-seven patients with primary stage I–III gastric cancer undergoing radical gastrectomy at the First Hospital of Lanzhou University.. Intervention: Overweight/obesity and/or metabolic syndrome (classified as Group B: overweight/obesity without MetS, or Group C: overweight/obesity with MetS).. Compared with: Group A (normal weight without metabolic syndrome).. n = 557. Single centre (First Hospital of Lanzhou University); location inferred to be China but not explicitly stated..
Group C (overweight/obesity with MetS) had worse OS than Group A (normal weight without MetS), P = 0.033 Group B (overweight/obesity without MetS) showed no significant OS difference versus Group A, P = 0.278 OS difference between Group C and Group B was not statistically significant, P = 0.163
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
Preoperative assessment of both BMI and metabolic syndrome components may help clinicians identify gastric cancer patients at higher postoperative mortality risk. However, the finding that MetS adds incremental risk beyond overweight/obesity alone was not statistically confirmed, so the practical utility of MetS stratification remains uncertain and requires validation in independent cohorts.
A single-centre retrospective cohort study with propensity-score matching showing MetS combined with overweight/obesity associates with worse overall survival in gastric cancer, but the MetS-alone increment over overweight/obesity alone was not statistically significant and the study is underpowered for a definitive practice recommendation.
As stated by the source record.
Quoted from the source exactly as published.
Preoperative assessment of both BMI and metabolic syndrome components may help clinicians identify gastric cancer patients at higher postoperative mortality risk. However, the finding that MetS adds incremental risk beyond overweight/obesity alone was not statistically confirmed, so the practical utility of MetS stratification remains uncertain and requires validation in independent cohorts.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
Overweight/obesity and metabolic syndrome (MetS) are recognized as potential risk factors for gastric cancer, but their impacts on postoperative morbidity and overall survival (OS) following radical gastrectomy remain controversial. We hypothesized that overweight/obesity and MetS represent successive stages of a progressive metabolic disorder, and aimed to investigate the effects of preoperative overweight/obesity and MetS on postoperative complications and OS, as well as the additional survival risk associated with MetS on the basis of overweight/obesity. Five-hundred-fifty-seven patients with primary stage I–III GC who underwent radical gastrectomy at the First Hospital of Lanzhou University between January 2017 and December 2021 were enrolled. Subjects were classified into three groups: Group A (normal weight without MetS), Group B (overweight/obesity without MetS), and Group C (overweight/obesity with MetS). After propensity-score-based baseline matching, OS was compared among the three groups. Univariate and multivariate Cox regression analyses were performed to identify independent predictors of OS. Restricted cubic spline (RCS) models were used to characterize the dose–response relationship between BMI and post-operative complications; threshold analysis of BMI as a continuous variable was employed to determine the optimal cut-off for risk stratification. Compared with Group A, Group B showed no significant difference in OS ( P = 0.278), while Group C had a worse OS ( P = 0.033). Although OS in Group C was lower than in Group B, the difference was not statistically significant ( P = 0.163). BMI displayed a U-shaped, non-linear association with post-operative complication rates ( P = 0.007); Threshold analysis revealed that both low and high BMI increased the risk of complications and identified the optimal cut-off value of BMI as 22.82 kg/m². Among patients with BMI ≥ 22.82 kg/m², complication rates rose progressively with the cumulative number of MetS components; subjects with ≥ 2 metabolic abnormalities had a higher complication risk than those with 0–1 abnormality ( P = 0.033). The combination of MetS on the basis of overweight/obesity is associated with an increased risk of postoperative mortality in gastric cancer. Preoperative assessment combining BMI and metabolic components may help identify high‑risk individuals and guide targeted interventions.
Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.