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Life sciences · Phase 4 Trial
ClinicalTrials.gov · October 16, 2026
No summary has been generated for this record yet. What follows is drawn from its source metadata only.
Phase 4 Trial.
No findings were extractable from the material analysed.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
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Registry record from ClinicalTrials.gov (NCT07298993). This is a study registration, not published results. Lead sponsor: Weill Medical College of Cornell University. Recruitment status: ENROLLING_BY_INVITATION. Phase: PHASE4. Study type: INTERVENTIONAL. Enrollment: 240 participants (ESTIMATED). Conditions: Heart Failure, HFpEF, HFpEF - Heart Failure With Preserved Ejection Fraction. Interventions: DRUG: Placebo (matching); DRUG: Beta-blockers. Primary outcome measures: The Hierarchical Composite Endpoint , From baseline (randomization) to 120 days after study drug initiation. Brief summary: The goal of this study is to learn whether stopping beta-blockers can help older adults with heart failure with preserved ejection fraction (HFpEF) feel better and function better. This study will test whether "deprescribing" or stopping these medications in a careful, guided way can improve symptoms and quality of life. Participants will be randomly assigned to one of two groups: Deprescribing group: Beta-blockers are gradually reduced using capsules that contain decreasing doses. Usual care group: Beta-blockers are continued at the usual dose in look-alike capsules. All participants will: * Take study medicine for about 4 months * Have their blood pressure and heart rate monitored * Complete regular phone calls and questionnaires about how they are feeling This study does not involve any experimental medication. Participants active involvement in the study will last approximately 4 months. During these 4 months they will have 8 scheduled telephone visits.