Life sciences · Phase 2 Trial
ClinicalTrials.gov · September 15, 2026
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Phase 2 Trial.
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Registry record from ClinicalTrials.gov (NCT07132918). This is a study registration, not published results. Lead sponsor: University of Wisconsin, Madison. Recruitment status: RECRUITING. Phase: PHASE2. Study type: INTERVENTIONAL. Enrollment: 60 participants (ESTIMATED). Conditions: Non-Small Cell Lung Cancer (Stage III), Esophageal Cancer Stage I-III, Esophagogastric Cancer Stage I-III, Thymoma and Thymic Carcinoma Stage II-III, Other Cancers in the Thoracic Region. Interventions: RADIATION: MRgART; RADIATION: LINAC. Primary outcome measures: Change in left ventricular ejection fraction (LVEF) , Pre-treatment, 3 months post-treatment, 6 months post-treatment. Brief summary: The goal of this clinical trial is to compare a new way of using magnetic resonance-guided adaptive radiation therapy (MRgART) to the standard of care linear accelerator (LINAC) radiation treatment in people with cancer in the thoracic region near the heart. The main question it aims to answer is whether MRgART affects the heart differently than LINAC. Participants will: * Receive radiation therapy * Undergo MRIs and bloodwork * Complete quality of life questionnaires