Life sciences · Preprint
arXiv · September 25, 2026
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Unobserved common causes are pervasive in real-world time series and can induce spurious associations that causal discovery methods mistake for direct edges. We propose LUCID (Learning Under Confounding for Inference and Discovery, a regime-adaptive deconfounding layer that first estimates the confounding regime from data using a Marčenko--Pastur spectral router, then applies a deconfounding strategy matched to that regime. When the spectrum indicates pervasive factor confounding, LUCID attenuates factor-dominated variation and recovers contemporaneous (lag-$0$) structure from the resulting innovations, with edge selection calibrated against a data-driven edge-free null. Rather than being tied to a particular discovery algorithm, it can wrap existing discovery engines; we demonstrate consistent improvements across three such methods. On a diverse synthetic out-of-distribution benchmark spanning changes in confounder strength and sparsity, loading density, lag structure, volatility dynamics, edge heterogeneity, persistence, intermittency, and tail behavior, LUCID achieves the best family-weighted directed, lag-resolved graph $F_1$ ($0.60$), improving over the strongest baseline by $0.19$ absolute ($\approx\!46\%$ relative). Its advantage widens relative to looser lag-collapsed scoring, and remains robust under intermittent and heavy-tailed confounding. Code reproducing the method, the benchmark generators, and every reported experiment is available at https://github.com/bloomberg/causal-ts.