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Life sciences · Interventional Study
ClinicalTrials.gov · September 25, 2026
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Interventional Study.
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Registry record from ClinicalTrials.gov (NCT07843082). This is a study registration, not published results. Lead sponsor: Oslo University Hospital. Recruitment status: COMPLETED. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 43 participants (ACTUAL). Conditions: Diabetes, Obesity & Overweight. Interventions: BEHAVIORAL: Exercise. Primary outcome measures: Change in postprandial whole-body insulin sensitivity measured as glucose metabolic clearance rate per unit insulin (MCR/I) , Baseline and 8 weeks (at the end of the 8-week exercise intervention); Change in fasting whole-body insulin sensitivity measured as glucose metabolic clearance rate per unit insulin (MCR/I) , Baseline and 8 weeks (at the end of the 8-week exercise intervention); Change in suppression of endogenous glucose production (EGP) during oral glucose tolerance test , Baseline and 8 weeks (at the end of the 8-week exercise intervention); Change in duration of suppression of endogenous glucose production (EGP) during oral glucose tolerance test , Baseline and 8 weeks (at the end of the 8-week exercise intervention); Change in suppression of glycerol rate of appearance (Ra) during oral glucose tolerance test , Baseline and 8 weeks (at the end of the 8-week exercise intervention); Change in duration of suppression of glycerol rate of appearance (Ra) during oral glucose tolerance test , Baseline and 8 weeks (at the end of the 8-week exercise intervention); Change in hepatic insulin resistance index (Hepatic IR) , Baseline and 8 weeks (at the end of the 8-week exercise intervention); Change in adipose tissue insulin resistance index (Lipo-IR) , Baseline and 8 weeks (at the end of the 8-week exercise intervention). Brief summary: South Asian women have a high risk of developing type 2 diabetes, and the risk is particularly high after gestational diabetes. This study examined whether eight weeks of supervised vigorous exercise improves insulin sensitivity in South Asian women with previous gestational diabetes, and whether the response differs from that of Nordic women with the same history. Participants trained four times per week, with two whole-body resistance sessions and two high-intensity interval cycling sessions. Before and after the intervention, insulin sensitivity was measured with an oral glucose tolerance test combined with stable-isotope tracers, and cardiorespiratory fitness, muscle strength and body composition were assessed. Blood, urine and tissue samples were collected for multi-omics analyses.