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Life sciences · Interventional Study
ClinicalTrials.gov · November 6, 2026
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Interventional Study.
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Registry record from ClinicalTrials.gov (NCT07553819). This is a study registration, not published results. Lead sponsor: Roswell Park Cancer Institute. Recruitment status: NOT_YET_RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 200 participants (ESTIMATED). Conditions: Lung Carcinoma. Interventions: PROCEDURE: Accelerometry; OTHER: Aerobic Exercise; PROCEDURE: Biospecimen Collection; OTHER: Educational Intervention; OTHER: Electronic Health Record Review; OTHER: Physical Performance Testing; PROCEDURE: Respiratory Muscle Training; OTHER: Supportive Care; OTHER: Survey Administration. Primary outcome measures: Compliance rate (Feasibility) , Up to 12 weeks; Adherence rate (Feasibility) , Up to 12 weeks; Assessing inspiratory and expiratory muscle strength , At baseline, 6 weeks, and 12 weeks; change in St. George Respiratory Questionnaire (SGRQ) , At baseline, 6 weeks, and 12 weeks; Functional capacity , At baseline, 6 weeks, and 12 weeks. Brief summary: This clinical trial studies whether home-based respiratory muscle training (RMT) and aerobic exercise (AE) programs can be used to improve lung health in current and former cigarette smokers. Lung cancer, the leading cause of cancer death, is overwhelmingly caused by exposure to cigarette smoke. Research suggests that daily activity reduces lung cancer risk in current and former smokers. However, current and former smokers are generally not active and new approaches to improve lung health are needed. During the home-based RMT program, participants use a handheld device to complete breathing exercise sessions consisting of breathing in and out against adjustable resistance. During the home-based AE program, participants complete aerobic exercises using a stationary bike working at a moderate workload against adjustable resistance. The home-based RMT and AE programs may be effective ways to strengthen the breathing muscles, which may improve lung health in current and former cigarette smokers.