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Cardiovascular Disease and Adiposity / Diabetes, Cardiovascular Risks, and Lipoproteins / Adipokines, Inflammation, and Metabolic Diseases · Journal article
Scientific Reports · August 7, 2026
Encouraging direction, but not yet definitive.
This cross-sectional study of 304 obese adults demonstrates that higher LAP tertiles are significantly associated with adverse cardiometabolic profiles including elevated blood pressure, unfavorable lipid parameters, and selected hematological alterations, with good discriminatory performance for metabolic syndrome (AUC 0.833). The findings suggest LAP may be a useful screening marker in obesity, but prospective studies are required to establish predictive value and temporal relationships.
Cross-sectional observational study. 304 obese participants; specific BMI threshold, age range, gender distribution, and recruitment setting not reported.. Intervention: Lipid Accumulation Product (LAP) stratification (highest vs. lowest tertile comparison). Compared with: Lowest LAP tertile; also compared against metabolic syndrome diagnosis for ROC analysis. n = 304.
Individuals in highest LAP tertile had significantly higher body weight, BMI, waist circumference, and waist-to-hip ratio than lowest tertile (all P < 0.05) Higher LAP tertiles associated with increased systolic and diastolic blood pressure, total cholesterol, triglycerides, and reduced HDL-C after adjustment White blood cell count and mean corpuscular hemoglobin remained significantly higher across LAP tertiles in fully adjusted models
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LAP may serve as a simple, accessible marker to screen obese patients for cardiometabolic risk without requiring additional blood tests beyond triglycerides. However, clinicians should await prospective evidence before incorporating LAP into routine risk stratification, as cross-sectional associations do not establish predictive utility or causality.
Cross-sectional study in 304 obese adults showing LAP correlates with metabolic and hematological markers with good discriminatory performance (AUC 0.833) for metabolic syndrome, but lacks prospective design and causal evidence needed to establish clinical utility.
As stated by the source record.
Quoted from the source exactly as published.
LAP may serve as a simple, accessible marker to screen obese patients for cardiometabolic risk without requiring additional blood tests beyond triglycerides. However, clinicians should await prospective evidence before incorporating LAP into routine risk stratification, as cross-sectional associations do not establish predictive utility or causality.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
The Lipid Accumulation Product (LAP) is recognized as an indicator of lipid-induced cellular stress. While its predictive value for conditions like diabetes, liver disease, and metabolic syndrome is established, its specific correlations with individual metabolic and hematological markers within the context of obesity remain less defined. This study sought to comprehensively investigate the links between LAP and a spectrum of metabolic and hematological biomarkers in individuals with obesity. This cross-sectional study involved 304 obese participants. Standard anthropometric measurements [weight, height, waist and hip circumference (WC, HC)] were taken, and dietary intake was assessed via a food frequency questionnaire. Blood samples were analyzed for glucose, insulin, hemoglobin A1C, serum lipids [total cholesterol, triglycerides, low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C)], and a complete blood cell count. LAP was calculated using WC and triglyceride levels. Participants were categorized into three tertiles based on their LAP values. Individuals in the highest LAP tertile had significantly higher body weight, body mass index, WC, and waist-to-hip ratio than those in the lowest tertile (all P < 0.05). Higher LAP tertiles were also associated with increased systolic and diastolic blood pressure, total cholesterol, triglycerides, and reduced HDL-C levels after adjustment for potential confounders. In addition, white blood cell count and mean corpuscular hemoglobin remained significantly higher across LAP tertiles in the fully adjusted models. Supplementary receiver operating characteristic (ROC) analysis demonstrated good discriminatory performance of LAP for identifying metabolic syndrome (AUC = 0.833; 95% CI: 0.779-0.887). Higher LAP was independently associated with an adverse cardiometabolic profile, characterized by greater adiposity, unfavorable lipid parameters, elevated blood pressure, and selected hematological alterations in adults with obesity. These findings support the potential utility of LAP as a simple and accessible marker for identifying individuals at increased cardiometabolic risk. However, prospective studies are needed to determine its predictive value and establish temporal relationships.
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