Life sciences · Preprint
arXiv · October 22, 2026
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Apple Silicon is among the most widely used platforms for local LLM inference, yet nearly all inference optimizations are designed and validated on server-class NVIDIA GPUs under batched serving workloads. Which optimizations retain their benefits when moved to Apple Silicon, and what determines their applicability? We evaluate four optimization families: KV-cache pruning, speculative decoding, ported GPU kernels, and post-training quantization. Experiments span four Apple machines under a common single-request decode workload, with matched RTX 4090 comparisons where possible. KV-cache pruning can reach up to 1.75 times end-to-end throughput on Apple but can reduce throughput on desktop NVIDIA GPUs. Under the common benchmark, all evaluated speculative decoding methods reduce throughput on Apple, despite reported 2-6 times gains on server GPUs. CUDA kernel designs transfer only partially: public Metal lacks asynchronous copy, and batch-one decode makes several serving-oriented mechanisms inapplicable, although transferable components yield up to 1.20 times decode throughput. Quantization gains vary by machine. Across four families, a reported speedup is not a portable property of a technique alone but a joint function of technique, runtime, hardware contract, and workload regime.