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Thyroid Cancer Diagnosis and Treatment / Management of Metastatic Bone Disease / Childhood Cancer Survivors' Quality of Life · Journal article
Frontiers in Endocrinology · September 10, 2026
Encouraging direction, but not yet definitive.
This retrospective cohort study reports that a multi-component adolescent-centered supportive care program was associated with significantly lower anxiety and depression scores at 6 months (adjusted P < 0.001), sustained improvements over time, and superior treatment adherence and social reintegration compared to routine care in 220 adolescents and young adults with differentiated thyroid cancer receiving radioiodine-131 therapy. The authors acknowledge that prospective randomized trials are needed to confirm causal efficacy; the retrospective design, absence of randomization, and reliance on historical controls limit the strength of causal inference.
Retrospective before-after cohort study with historical controls. 220 eligible patients aged 13–25 years with differentiated thyroid cancer receiving radioiodine-131 therapy; control group n=85 receiving routine care, observation group n=135 receiving supportive care program.. Intervention: Multi-component adolescent-centered supportive care program comprising narrative medicine interviews, radiation education, fertility and career counseling, social adaptation training, and sustained follow-up.. Compared with: Routine care (control group). n = 220. Not specified in the source text..
Observation group exhibited significantly lower 6-month SAS (anxiety) and SDS (depression) scores compared to control (adjusted P < 0.001) Significant group×time interactions for both anxiety and depression scales demonstrated sustained psychological improvements in observation group Treatment adherence superior in observation group (aOR = 2.71, 95% CI: 1.52–4.83)
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
The results suggest that a structured, multi-component supportive care program addressing psychological, educational, fertility, and social needs may improve mental health and treatment engagement in adolescents with thyroid cancer. However, clinicians should recognize that the retrospective, non-randomized design cannot definitively prove causality, and adoption should be considered provisional pending prospective randomized trial confirmation.
A retrospective before-after cohort study with historical controls showing clinically meaningful improvements in anxiety, depression, adherence, and social outcomes in adolescents with thyroid cancer, but requiring prospective RCT confirmation to establish causality.
As stated by the source record.
Quoted from the source exactly as published.
The results suggest that a structured, multi-component supportive care program addressing psychological, educational, fertility, and social needs may improve mental health and treatment engagement in adolescents with thyroid cancer. However, clinicians should recognize that the retrospective, non-randomized design cannot definitively prove causality, and adoption should be considered provisional pending prospective randomized trial confirmation.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
Background Adolescents and young adults (AYAs) with differentiated thyroid cancer (DTC) undergoing radioiodine-131 ( 131 I) therapy endure unique developmental and psychosocial challenges, yet evidence for adolescent-tailored supportive interventions remains scarce. This retrospective before-after cohort program is associated with improvements in psychological distress, treatment adherence, and social reintegration. Methods We enrolled 220 eligible patients aged 13–25 years with DTC receiving 131 I therapy (2016-2024). The control group (n=85) received routine care, while the observation group (n=135) received a multi-component supportive care program. It included narrative medicine interviews, radiation education, fertility and career counseling, social adaptation training, and sustained follow-up. Primary outcomes were anxiety (SAS) and depression (SDS) scores. Secondary outcomes covered adherence, social adaptation, fertility cognition and satisfaction. Linear mixed-effects models analyzed repeated SAS/SDS data; propensity score inverse probability weighting(IPTW), multivariable regression and Benjamini–Hochberg FDR correction were applied to adjust confounders and handle multiple comparisons. Results In linear mixed-effects models, the observation group exhibited significantly lower 6-month SAS and SDS scores (all adjusted P < 0.001).Significant group×time interactions for both scales demonstrated sustained psychological improvements. In multivariable logistic regression analyses adjusting for potential confounders, the observation group also achieved superior treatment adherence( aOR = 2.71, 95 %CI: ( 1.52 – 4.83 ), school/work resumption rates ( aOR = 2.35, 95 % CI: 1.22 − 4.51 ), and medical satisfaction ( aOR = 2.01, 95 % CI: 1.11 − 3.64 ) ( allFDR − P < 0.05 ).IPTW sensitivity analyses corroborated these findings. Exploratory subgroup analyses did not reveal consistent evidence of differential intervention effects across most subgroups. Conclusion A standardized adolescent-centered supportive care program was associated with persistent anxiety and depression relief, improved adherence and social reintegration among AYAs with DTC receiving 131 I therapy. While these real-world findings support program feasibility, prospective multicenter randomized trials are required to confirm causal efficacy.
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