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Life sciences · Review
Antibiot Khimioter = Antibiotics and Chemotherapy · September 5, 2026
A consensus or society position rather than new primary data.
This narrative review synthesizes evidence that rapid diagnostic methods for pathogen identification and resistance mechanism detection can reduce time to appropriate therapy, facilitate de-escalation, and reduce unnecessary antibiotic use, with greatest clinical benefit when integrated into antimicrobial stewardship teams. However, the authors acknowledge that heterogeneous data on patient-centred outcomes (mortality, length of stay, costs) limit the strength of conclusions and reflect substantial variation in local epidemiology, technology availability, and clinical implementation.
Narrative review. Clinical literature on rapid diagnostic methods for pathogen identification and antibiotic resistance detection in infections caused by ESKAPE pathogens and other resistant Gram-negative bacteria.. Intervention: Rapid diagnostic methods: multiplex PCR panels, MALDI-TOF MS, rapid phenotypic antimicrobial susceptibility testing, metagenomic sequencing, and ancillary biomarkers.. Compared with: Standard or conventional diagnostic and antimicrobial therapy selection (not explicitly detailed in the source)..
Rapid diagnostics can shorten time to appropriate therapy and accelerate escalation upon detection of resistant strains Rapid methods facilitate de-escalation and reduce unnecessary antibiotic use Most pronounced clinical effect achieved with integration into antimicrobial stewardship programs involving microbiologists, clinical pharmacologists, and infectious disease specialists
Review does not quantify the magnitude of time reduction to appropriate therapy or provide absolute risk reduction for mortality or hospital stay Most pronounced clinical effect achieved with integration into antimicrobial stewardship programs involving microbiologists, clinical pharmacologists, and infectious disease specialists
Clinicians and antimicrobial stewardship teams should consider integrating rapid diagnostic methods (multiplex PCR, MALDI-TOF MS, rapid AST, metagenomic sequencing) into their practice to optimize antibiotic selection and de-escalation. Implementation requires multidisciplinary collaboration and awareness that local epidemiology and laboratory infrastructure substantially influence effectiveness.
A narrative review synthesizing evidence on rapid diagnostic methods for pathogen identification and resistance detection, offering expert synthesis rather than original clinical trial data or definitive quantitative evidence of practice impact.
As stated by the source record.
Quoted from the source exactly as published.
Clinicians and antimicrobial stewardship teams should consider integrating rapid diagnostic methods (multiplex PCR, MALDI-TOF MS, rapid AST, metagenomic sequencing) into their practice to optimize antibiotic selection and de-escalation. Implementation requires multidisciplinary collaboration and awareness that local epidemiology and laboratory infrastructure substantially influence effectiveness.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
Antibiotic resistance represents one of the pressing challenges of contemporary clinical practice, as it contributes to increased mortality, prolonged hospitalization, and a growing economic burden on healthcare systems. This problem is of particular significance in infections caused by ESKAPE pathogens, carbapenem-resistant Enterobacteriaceae, Acinetobacter baumannii, and Pseudomonas aeruginosa, for which the timely selection of rational antibacterial therapy directly affects prognosis. The aim of the present review is to synthesize current evidence on the value of rapid methods for pathogen identification and antibiotic resistance mechanism detection in optimizing antibiotic therapy. The literature search was conducted in PubMed/MEDLINE, eLibrary, CyberLeninka, Google Scholar, Springer Link, and ScienceDirect; a total of 70 publications were included in the analysis. The capabilities of multiplex PCR panels, MALDI-TOF MS, rapid phenotypic antimicrobial susceptibility testing methods, metagenomic sequencing, and ancillary biomarkers are examined. It has been demonstrated that rapid diagnostics can shorten the time to appropriate therapy, accelerate escalation upon detection of resistant strains, facilitate de-escalation, and reduce unnecessary antibiotic use. The most pronounced clinical effect is achieved when rapid diagnostic tests are integrated into antimicrobial stewardship programs involving microbiologists, clinical pharmacologists, and infectious disease specialists. At the same time, data on the impact of rapid diagnostics on mortality rates, length of hospital stay, and economic costs remain heterogeneous, which is attributable to local epidemiological indicators, the availability of technologies, the organization of laboratory workflows, and the quality of clinical interpretation of results.
Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.