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Life sciences · Journal article
Antibiot Khimioter = Antibiotics and Chemotherapy · September 5, 2026
Early or partial results. Treat as a signal, not a conclusion.
This is a preliminary fungal screening study that identifies three basidiomycete strains (Cyclocybe cylindracea, Stropharia rugosoannulata, and Hypsizygus ulmarius) as potential producers of sterol biosynthesis inhibitors based on in vitro assays. The work establishes feasibility for further compound characterization but provides no quantified potency data, clinical relevance, or comparison to existing inhibitors.
Descriptive in vitro screening study. Four basidiomycete strains cultured by submerged fermentation method. Intervention: Fungal extracts from C. cylindracea, H. erinaceus, S. rugosoannulata, and H. ulmarius.
Three of four basidiomycete strains (C. cylindracea, S. rugosoannulata, H. ulmarius) showed activity in H. salinarum microbial system for sterol biosynthesis inhibition C. cylindracea and H. ulmarius strains demonstrated ability to inhibit early stages of sterol biosynthesis before mevalonate formation All four strains exhibited antibacterial and antifungal activity in standard assays
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
This work identifies natural fungal sources for potential drug discovery but is too preliminary for clinical application. Further work must isolate, characterize, and quantify active compounds before any clinical assessment.
This is an early-stage screening study identifying fungal strains with potential to produce bioactive compounds; it demonstrates feasibility but lacks clinical validation, quantified effect sizes, or comparison to known standards.
As stated by the source record.
This work identifies natural fungal sources for potential drug discovery but is too preliminary for clinical application. Further work must isolate, characterize, and quantify active compounds before any clinical assessment.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
What is missing. This record has no reported figures. That is a gap in the analysis, not a judgement about the study.
Background. Treatment of infectious, tumor, and cardiovascular diseases remains the most important task of modern medicine. The search for biologically active secondary metabolites allows us to detect natural compounds that can serve as the basis for the development of fundamentally new drugs. The use of original search methods and the involvement of new groups of organisms, including basidiomycetes, can significantly increase the efficiency of screening work and, ultimately, lead to the development of new, more effective drugs. The aim of the work was to reveal the ability of Basidiomycetes to produce sterol biosynthesis inhibitors (SBIs) and metabolites with antimicrobial properties. Material and methods. Basidiomycetes were grown using the submerged cultivation method. Biologically active compounds were obtained by extraction with ethyl acetate from the culture broth and with ethanol from the mycelium of the producers. The antibacterial and antifungal activity of the extracts with determination of the minimum inhibitory concentration was assessed using the serial dilution method in liquid media, as well as the agar diffusion assay. To detect SBIs, a test system with Halobacterium salinarum microbial culture, which possesses the mevalonate pathway of sterol biosynthesis, was used. Results. Basidiomycete strains belonging to the species C yclocybe cylindracea, Hericium erinaceus, Stropharia rugosoannulata and Hypsizygus ulmarius grown by submerged cultivation showed antibacterial and antifungal activity. In the microbial system of H. salinarum, the studied strains of C. cylindracea, S. rugosoannulata and H. ulmarius showed themselves as possible producers of SBIs. The strains C. cylindracea and H. ulmarius revealed the ability to form inhibitors of the early stages of sterol biosynthesis before the mevalonate formation. Conclusion. Among the 4 studied basidiomycete strains, 3 strains — C. cylindracea, S. rugosoannulata, and H. ulmarius — were identified as potential producers of SBIs. C. cylindracea and H. ulmarius strains demonstrated the ability to produce inhibitors of the early stages of sterol biosynthesis.
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