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Life sciences · Phase 1 Trial
ClinicalTrials.gov · October 5, 2026
No summary has been generated for this record yet. What follows is drawn from its source metadata only.
Phase 1 Trial.
No findings were extractable from the material analysed.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
The source did not state who this applies to in practice.
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Registry record from ClinicalTrials.gov (NCT07164313). This is a study registration, not published results. Lead sponsor: Zymeworks BC Inc.. Recruitment status: RECRUITING. Phase: PHASE1. Study type: INTERVENTIONAL. Enrollment: 140 participants (ESTIMATED). Conditions: Hepatocellular Carcinoma, Squamous Cell Non-Small Cell Lung Cancer, Germ Cell Tumor. Interventions: DRUG: ZW251. Primary outcome measures: Incidence of dose-limiting toxicities (DLTs; Part 1) , Up to 3 weeks; Incidence of AEs (Parts 1 and 2) , Up to approximately 2 years; Incidence of clinical laboratory abnormalities (Parts 1 and 2) , Up to approximately 2 years; Objective response rate (Part 2) , Up to approximately 2 years. Brief summary: The purpose of this study is to find out if ZW251, an antibody-drug conjugate targeting glypican-3 (GPC3), is safe and can treat participants with advanced cancers, including hepatocellular carcinoma (HCC), squamous cell non-small cell lung cancer (NSCLC), or germ cell tumors (GCT).