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Mood Disorders / Depression / Mood Disorder Risk · Journal article
Journal of Affective Disorders · August 12, 2026
Early or partial results. Treat as a signal, not a conclusion.
This is a baseline descriptive report from two prospective cohort studies comparing clinical and psychological profiles of 75 adolescents with suicidal behavior, 75 at-risk for mood disorders, and 75 healthy controls. Adolescents with suicidal behavior show markedly higher rates of depression, anxiety, hopelessness, and low optimism, while both suicidal and at-risk groups exhibit higher irritability, borderline personality disorder features, and lower resilience than healthy controls. The work is framed as hypothesis-generating; longitudinal analysis and biological data collection are ongoing.
Descriptive baseline analysis from two prospective cohort studies. Adolescents enrolled in two prospective cohort studies: 'Characterizing the Inflammatory Profile and Suicidal Behavior in Adolescents' and 'RAD arm of the Texas Resilience Against Depression'. Three groups: suicidal behavior (n=75), at-risk for mood disorders (n=75), healthy controls (n=75). Age, g…. Compared with: Healthy adolescent controls; between-group cross-sectional comparison. n = 225.
Adolescents with suicidal behavior reported 3.53 lifetime suicidal events on average Suicidal group: moderate to very severe depression 34.7%–9.3%, moderate to severe anxiety 58.6%, low optimism 91.9%, mild to moderate hopelessness 39.2%–28.4% At-risk group: no depression 60%, no anxiety 68.9%, moderate optimism 50%, positive outlook 85.7%
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Clinicians should interpret this as a descriptive snapshot of baseline differences among high-risk adolescent groups, useful for understanding the symptom burden and psychological profiles of suicidal versus at-risk youth. This does not yet predict outcomes or guide treatment decisions; longitudinal follow-up and biological markers are being analyzed and may yield actionable findings.
Descriptive baseline characterization of three adolescent groups from two prospective cohort studies; no causal inference, intervention, or outcome prediction reported—suitable for hypothesis generation and future mechanistic work.
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Quoted from the source exactly as published.
Clinicians should interpret this as a descriptive snapshot of baseline differences among high-risk adolescent groups, useful for understanding the symptom burden and psychological profiles of suicidal versus at-risk youth. This does not yet predict outcomes or guide treatment decisions; longitudinal follow-up and biological markers are being analyzed and may yield actionable findings.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
Suicide is one of the leading causes of death among adolescents, yet little is understood about the biopsychosocial factors related to suicidality. The demographic, clinical, and biological characteristics of adolescents with and without psychiatric histories may help inform mechanistic approaches to treatment of mood disorders and suicidality. The 'characterizing the inflammatory profile and suicidal behavior in adolescents' and 'RAD arm of the Texas Resilience Against Depression' studies aimed to characterize the clinical and biological profiles of youth with suicidal behavior and youth at risk for mood disorders, compared to healthy adolescents (n = 75 in each group). Here, we report the descriptive baseline clinical and psychological characteristics of adolescents at risk of mood disorders and those with suicidal behavior. The adolescents with suicidal behavior reported 3.53 lifetime suicidal events on average, predominantly reported moderate to very severe depression (34.7%, 24%, to 9.3%), moderate to severe anxiety (58.6%), low optimism (91.9%), and mild (39.2%) to moderate (28.4%) degree of hopelessness. The at-risk adolescents predominantly reported no depression (60%) or anxiety (68.9%), moderate optimism (50%), and a positive outlook (85.7%). Healthy adolescents predominantly reported no depression (88.3%) or anxiety (93.2%), moderate optimism (59%), and a positive outlook (87%). The adolescents with suicidal behavior and those at risk of mood disorders exhibited significantly higher irritability and borderline personality disorder features (uncorrected p = 0.02 to p < 0.001) and lower resilience compared to healthy adolescents. Ongoing investigations using the longitudinal clinical and biological data will help identify the immune biosignatures of suicidality in youth.
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