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Depression / Growth Mindset · Observational Study
ClinicalTrials.gov · August 13, 2026
Early or partial results. Treat as a signal, not a conclusion.
This is a registry record for an active observational study characterizing depression in adolescents aged 11–17, with optional treatment via IPT-A or CBT over up to 25 weeks. No outcome results are reported in this registry record; the study is still recruiting and remains ongoing.
Observational. Depression; age from 11 Years; to 25 Years; accepts healthy volunteers. Intervention: Adolescents with major depression; Healthy volunteer adolescents/young adults; Parents of adolescent participants. Compared with: Observational comparison to adolescents without mental health diagnoses; no active comparator arm specified. n = 4,100. 3 sites: United States.
This is a registry record for an active observational study characterizing depression in adolescents aged 11–17, with optional treatment via IPT-A or CBT over up to 25 weeks. No outcome results are reported in this registry record; the study is still recruiting and remains ongoing.
No data reported on effect sizes, completion rates, adverse events, or any clinical outcomes.
This study aims to characterize depression and its treatment in adolescents and understand associated brain changes. Results, when available, may inform understanding of depression mechanisms and comparative effectiveness of IPT-A versus CBT in this age group, but no outcome data are yet available.
This is a registry record for an ongoing observational study with no results reported; recruitment is active and follow-up extends to two years, making this an early-stage characterization and treatment study without outcome data.
As stated by the source record.
Quoted from the source exactly as published.
This study aims to characterize depression and its treatment in adolescents and understand associated brain changes. Results, when available, may inform understanding of depression mechanisms and comparative effectiveness of IPT-A versus CBT in this age group, but no outcome data are yet available.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
What is missing. This record has no key findings. That is a gap in the analysis, not a judgement about the study.
Registry record from ClinicalTrials.gov (NCT03388606). This is a study registration, not published results. Lead sponsor: National Institute of Mental Health (NIMH). Recruitment status: RECRUITING. Study type: OBSERVATIONAL. Enrollment: 4100 participants (ESTIMATED). Conditions: Depression. Interventions: BEHAVIORAL: Growth Mindset. Primary outcome measures: Mood and Feelings Questionnaire , ongoing. Brief summary: This research study seeks to find causes and treatments of depression in teenagers. The study goals are to increase our knowledge of treatments for depression and understand how the brain changes when teenagers have depression. The study will also compare teenagers with depression to those without mental health diagnoses. This outpatient study is recruiting participants ages 11-17 who are depressed. They must have a pediatrician or other medical provider, be medically healthy, and able to perform research tasks. They may not currently be hospitalized, psychotic or actively suicidal. Teenagers with depression are eligible even if they are taking medication. The study begins with an evaluation that includes clinical assessment, interviews, and questionnaires. * Visits may include paper-and-pencil and computer tests of mood, memory, and thinking; specialized computer games; and structural and brain imaging. If eligible, study participants may return several times a year for up to two years. This part of the study does not involve treatment. * Participants may be eligible for outpatient treatment for up to 25 weeks. This includes evidenced-based "talk" therapy. Participants may choose either Interpersonal Psychotherapy for Adolescents (IPT-A) or Cognitive Behavioral Therapy (CBT). If indicated, participants may opt to receive standard medication treatments along with psychotherapy. Research includes computer tasks and brain imaging. All clinical evaluations, research tasks and visits are free of cost. Participants are compensated for research activities. Parents and teenager must agree to the teenager s participation in research. The study is conducted at the NIH in Bethesda, Maryland and enrolls participants from the Washington DC Metro region within 50 miles of NIH. Transportation expenses are reimbursed by NIMH....
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