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Life sciences · Journal article
Infection Prevention in Practice · August 7, 2026
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Introduction. Multi-drug-resistant Gram-negative bacteria (MDR-GNB) are a major healthcare challenge, particularly among patients admitted to intensive care units (ICUs). The objective of the current study was to assess the risk of acquisition of MDR-GNB in ICU patients and the associated risk factors and outcomes.Methods. A prospective cohort study among adult ICU patients was conducted in two tertiary care hospitals in Riyadh, Saudi Arabia, between 2021 and 2022. Specimens were examined at admission, during stay, and before discharge for all patients. Acquisition of MDR-GNB was confirmed by a positive culture/polymerase chain reaction before discharge among patients who were negative at admission.Results. A total of 307 patients were included. The mean age was 56.7 ± 18.2 years and 62.2% were males. Out of 307, 82 (26.7%) patients acquired MDR-GNB during their ICU stay. The most common MDR-GNB pathogens were Klebsiella spp. (47.1%), Acinetobacter spp. (14.7%), Pseudomonas aeruginosa (12.7%), Enterobacter spp. (10.8%), and Escherichia coli (5.9%). Approximately 40.2% of MDR-GNB presented as infection and 59.8% as colonization. In multi-variate analysis, the following variables were independent predictors of MDR-GNB acquisition; pneumonia at admission, central line use, urinary catheter use, renal comorbidity, and prolonged hospitalization. Patients who acquired MDR-GNB had significantly higher mortality (34.1% vs 5.3%, P<0.001) and ICU length of stay (median of 26 vs 10 days, P<0.001).Conclusions. The findings underscore the high risk and burden of MDR-GNB acquisition in the ICU setting. There is an urgent need for enhanced infection control strategies and antimicrobial stewardship activities to reduce MDR-GNB acquisition and its negative impact.