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Obesity / Heart Failure / Weight Loss · Observational Study
ClinicalTrials.gov · August 13, 2026
Early or partial results. Treat as a signal, not a conclusion.
This is a completed observational study examining how bariatric surgery affects cardiometabolic exercise performance in patients with heart failure with preserved ejection fraction or obesity. No results are reported in this registry record; the study enrolled 21 participants and measured peak VO2 from baseline to 12 months as the primary outcome.
Observational. Heart Failure, Obesity, Weight Loss, Heart Failure With Preserved Ejection Fraction; age from 40 Years. Intervention: Weight Loss Procedure. n = 21. 1 site: United States.
This is a completed observational study examining how bariatric surgery affects cardiometabolic exercise performance in patients with heart failure with preserved ejection fraction or obesity. No results are reported in this registry record; the study enrolled 21 participants and measured peak VO2 from baseline to 12 months as the primary outcome.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
Results from this study are not yet available in the registry record. When published, findings may inform understanding of whether weight loss interventions reverse cardiometabolic dysfunction in HFpEF, but the small observational design limits generalizability.
This is a completed observational registry study with small enrollment (n=21) examining cardiometabolic responses to exercise after bariatric surgery; results are not yet reported in this registry record.
As stated by the source record.
Quoted from the source exactly as published.
Results from this study are not yet available in the registry record. When published, findings may inform understanding of whether weight loss interventions reverse cardiometabolic dysfunction in HFpEF, but the small observational design limits generalizability.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
What is missing. This record has no key findings. That is a gap in the analysis, not a judgement about the study.
Registry record from ClinicalTrials.gov (NCT06576050). This is a study registration, not published results. Lead sponsor: Massachusetts General Hospital. Recruitment status: COMPLETED. Study type: OBSERVATIONAL. Enrollment: 21 participants (ACTUAL). Conditions: Heart Failure, Obesity, Weight Loss, Heart Failure With Preserved Ejection Fraction. Primary outcome measures: Change in Peak VO2 , baseline to month 12. Brief summary: The goal of this study is to define how treatment of obesity impacts cardiometabolic performance during exercise in patients with established HFpEF or at risk for HFpEF. Multi-dimensional physical activity, including 6 minute walk distance, resting metabolic rate, the metabolic cost of initiating exercise, and low-level, intermediate, peak exercise, and recovery oxygen utilization patterns will be examined in relation to weight loss in people having bariatric surgery. The investigators also aim to learn more about the relationship between obesity, exercise intolerance, and heart failure with preserved ejection fraction (HFpEF). The investigators are interested in the extent to which HFpEF\'s manifestations are preventable or reversible with weight-loss interventions. The main questions it aims to answer are: 1. How does weight loss surgery affect comprehensive measures of physical activity? 2. What are the biochemical signatures of obesity and their reversibility in patients with HFpEF and obesity?
Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.