Loading
Breast Lesions and Carcinomas / Advanced Breast Cancer Therapies · Journal article
Journal of Istanbul Faculty of Medicine / İstanbul Tıp Fakültesi Dergisi · August 14, 2026
Early or partial results. Treat as a signal, not a conclusion.
This is a single-patient case report of marked clinical improvement (resolution of dyspnea, pleural effusion, and visual symptoms) following combination systemic therapy (ovarian suppression, letrozole, ribociclib, and denosumab) in a premenopausal woman with HR+/HER2− breast cancer, pleural involvement, bone metastases, and rare choroidal metastasis. The report is descriptive and does not permit attribution of benefit to any single agent or estimation of effect size; it serves to document a clinical scenario and illustrate the potential for rapid ophthalmologic assessment and timely systemic therapy.
Case report. One 49-year-old premenopausal woman with HR+/HER2− metastatic breast cancer involving pleura, bones, and right choroid, presenting with dyspnea, back pain, blurred vision, and impending visceral crisis (progressive respiratory dysfunction and recurrent pleural effusion despite drainage).. Intervention: Combination systemic therapy: ovarian suppression, letrozole, ribociclib, and denosumab. n = 1.
49-year-old premenopausal woman with HR+/HER2− metastatic breast cancer involving pleura, bones, and choroid Choroidal metastases occur in approximately 2–7% of metastatic breast cancer cases Marked systemic improvement and complete resolution of visual symptoms achieved with combination therapy
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
This case illustrates the need for ophthalmologic assessment in breast cancer patients with visual symptoms and suggests that rapid initiation of systemic therapy may induce regression of choroidal metastases. However, as a single uncontrolled observation, it cannot be used to guide treatment selection or predict outcomes in similar patients.
A single-patient case report with no control group, showing clinical response to combination therapy in a rare presentation; raises questions about ribociclib efficacy in visceral crisis but cannot establish causation or generalizability.
As stated by the source record.
Quoted from the source exactly as published.
This case illustrates the need for ophthalmologic assessment in breast cancer patients with visual symptoms and suggests that rapid initiation of systemic therapy may induce regression of choroidal metastases. However, as a single uncontrolled observation, it cannot be used to guide treatment selection or predict outcomes in similar patients.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
Choroidal metastases represent a rare manifestation of metastatic breast cancer, occurring in approximately 2–7% of cases, and typically indicate advanced systemic disease with poor prognosis.We report a 49-year-old premenopausal woman with hormone receptor–positive, HER2-negative metastatic breast carcinoma involving the pleura and bones. She presented with progressive dyspnea, back pain, and blurred vision in the right eye. Imaging revealed a large malignant pleural effusion, extensive osteolytic lesions, and a left breast mass with axillary lymphadenopathy. Ophthalmologic evaluation confirmed a right choroidal metastasis.Given her worsening respiratory function and recurrent pleural effusion despite drainage, the clinical picture was consistent with an impending visceral crisis. Systemic treatment with ovarian suppression, letrozole, ribociclib, and denosumab was promptly initiated.Follow-up revealed marked systemic improvement and complete resolution of visual symptoms. This case underscores the importance of rapid ophthalmologic assessment in patients with breast cancer with visual complaints. It highlights that timely systemic therapy may induce regression of choroidal lesions and prevent progression to overt visceral crisis.
Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.