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Biological Research and Disease Studies / Parasitic Diseases Research and Treatment / Mosquito Borne Diseases and Control · Journal article
Advances in Clinical Medical Research · August 16, 2026
Encouraging direction, but not yet definitive.
This single-centre cross-sectional study identified DENV-2 as the predominant circulating serotype (46.3% of confirmed cases) and demonstrated a statistically significant association between DENV-2 infection and severe dengue (OR 2.91; 95% CI 1.28–6.62; p=0.009). Platelet count <50,000/µL, bleeding manifestations, and abdominal pain were identified as independent predictors of severity. The findings are hypothesis-generating for serotype-severity relationships but are not confirmatory of causation and require validation in larger, prospective cohorts.
Cross-sectional observational study. Clinically suspected dengue patients presenting to a tertiary care hospital in Indore, Madhya Pradesh, Central India. Eligibility and exclusion criteria not specified.. Intervention: Molecular serotyping by RT-PCR and clinical/hematological assessment. n = 290. Single centre: tertiary care hospital in Indore, Madhya Pradesh, Central India.
DENV-2 was predominant (31/67, 46.3%) among RT-PCR-confirmed cases, followed by DENV-3 (18/67, 26.9%), DENV-1 (14/67, 20.9%), and DENV-4 (2/67, 3.0%) DENV-2 infection significantly associated with severe dengue: OR 2.91 (95% CI 1.28–6.62; p=0.009) Platelet count <50,000/µL was the strongest predictor of severity (OR 4.72; 95% CI 2.01–11.08; p<0.001)
Bleeding manifestations (OR 3.18; p=0.011) and abdominal pain (OR 2.37; p=0.039) independently associated with severe dengue
Clinicians in dengue-endemic regions should note that DENV-2 predominance may warrant heightened surveillance for severe outcomes. Platelet count <50,000/µL combined with DENV-2 serotyping and clinical indicators (bleeding, abdominal pain) may help triage risk; however, this single-centre finding requires replication before altering clinical practice.
A cross-sectional molecular epidemiology study with confirmed RT-PCR diagnosis linking DENV-2 predominance to severe dengue via multivariate logistic regression, but limited by single-centre design and modest sample size of confirmed cases.
As stated by the source record.
Quoted from the source exactly as published.
Clinicians in dengue-endemic regions should note that DENV-2 predominance may warrant heightened surveillance for severe outcomes. Platelet count <50,000/µL combined with DENV-2 serotyping and clinical indicators (bleeding, abdominal pain) may help triage risk; however, this single-centre finding requires replication before altering clinical practice.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
Background: Dengue is an important mosquito-borne viral infection with considerable variation in circulating serotypes and disease severity. Molecular surveillance helps identify predominant serotypes and their association with clinical outcomes. This study evaluated the circulating dengue virus serotypes and their relationship with disease severity in patients from Central India. The aim & objective is to investigate the molecular epidemiology of circulating dengue virus serotypes, identify DENV-1 to DENV-4 by RT-PCR, determine their demographic and clinical distribution, assess their association with disease severity, and generate data to strengthen dengue surveillance and public health interventions. Materials and Methods: A cross-sectional observational study was conducted among 290 clinically suspected dengue patients at a tertiary care hospital in Indore, Madhya Pradesh, from January 2023 to January 2026. Serum samples were screened using the SD BIOLINE™ Dengue Duo Rapid Test. Dengue viral RNA was detected and serotyped using the RealStar® Dengue Type RT-PCR Kit 1.0. Clinical manifestations and hematological parameters were recorded, and multivariate logistic regression was used to identify factors associated with severe dengue. Results: Rapid testing was positive in 61 (21.0%) patients, while real-time RT-PCR confirmed dengue infection in 67 (23.1%). Among RT-PCR-positive cases, DENV-2 was predominant (31, 46.3%), followed by DENV-3 (18, 26.9%), DENV-1 (14, 20.9%), and DENV-4 (2, 3.0%); mixed-serotype infection occurred in 2 (3.0%) cases. DENV-2 infection was significantly associated with severe dengue (OR 2.91, 95% CI: 1.28–6.62; p=0.009). Platelet count <50,000/µL was the strongest predictor (OR 4.72, 95% CI: 2.01–11.08; p<0.001), followed by bleeding manifestations (OR 3.18; p=0.011) and abdominal pain (OR 2.37; p=0.039). Vomiting, abdominal pain, bleeding, and hypotension were significantly associated with serotype. Conclusion: DENV-2 was the predominant circulating serotype and showed a significant association with severe dengue. Molecular serotyping combined with clinical and hematological assessment may improve recognition of patients at risk of severe disease.
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