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Life sciences · Phase 2 Trial
ClinicalTrials.gov · September 22, 2026
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Phase 2 Trial.
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Registry record from ClinicalTrials.gov (NCT07583550). This is a study registration, not published results. Lead sponsor: Jiangmen Central Hospital. Recruitment status: RECRUITING. Phase: PHASE2. Study type: INTERVENTIONAL. Enrollment: 43 participants (ESTIMATED). Conditions: Lung, Radiotherapy. Interventions: DRUG: Etoposide; DRUG: Cisplatin; DRUG: Carboplatin; DRUG: Adebrelimab; RADIATION: Thoracic Radiotherapy. Primary outcome measures: Progression-Free Survival（PFS） , From the date of first radiotherapy to the date of first documented disease progression, metastasis.. Brief summary: This study is a multicenter, prospective investigation aiming to evaluate the efficacy and safety of low-dose radiotherapy (15Gy/1.5 Gy bid × 10 fractions) combined with 4-6 cycles of systemic chemotherapy concurrently with Adebrelimab, followed by Adebrelimab maintenance therapy for up to two years, in subjects with extensive-stage small cell lung cancer (ES-SCLC). Additionally, immunohistochemical detection of the expression levels of four key transcriptional proteins-YAP1, NEUROD1, ASCL1, and POU2F3-will be performed to guide the molecular subtyping of SCLC. Based on these findings, we will explore the differential therapeutic outcomes of this regimen across distinct molecular subtypes (A/N/P/Y/I/AN/QN), with the goal of identifying the subject population most likely to benefit from this treatment modality, thereby optimizing clinical decision-making.