Life sciences · Phase 2 Trial
ClinicalTrials.gov · October 28, 2026
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Phase 2 Trial.
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Registry record from ClinicalTrials.gov (NCT06741085). This is a study registration, not published results. Lead sponsor: Memorial Sloan Kettering Cancer Center. Recruitment status: RECRUITING. Phase: PHASE2. Study type: INTERVENTIONAL. Enrollment: 56 participants (ESTIMATED). Conditions: Non Small Cell Lung Cancer Metastatic. Interventions: DRUG: osimertinib; RADIATION: stereotactic radiosurgery (SRS). Primary outcome measures: intracranial progression-free survival (iPFS) , 3 months. Brief summary: The researchers are doing this study is to find out whether treating brain metastasis with SRS after 3 months of therapy with osimertinib is better than treating with osimertinib alone in people with NSCLC. The researchers will also look at how the study intervention impacts participants' quality of life. The researchers will measure quality of life by having participants complete questionnaires.