Life sciences · Phase 3 Trial
ClinicalTrials.gov · September 18, 2026
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Phase 3 Trial.
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Registry record from ClinicalTrials.gov (NCT04665856). This is a study registration, not published results. Lead sponsor: Hoffmann-La Roche. Recruitment status: COMPLETED. Phase: PHASE3. Study type: INTERVENTIONAL. Enrollment: 123 participants (ACTUAL). Conditions: Small Cell Lung Carcinoma. Interventions: DRUG: Tiragolumab; DRUG: Atezolizumab; DRUG: Carboplatin; DRUG: Etoposide; DRUG: Tiragolumab Matching Placebo. Primary outcome measures: Investigator-assessed Progression-free Survival (PFS) in the Primary Analysis Set (PAS) , From randomization to first occurrence of PD or death from any cause, whichever occurred first (up to approximately 32.3 months); Overall Survival (OS) in the PAS , From randomization to death from any cause (up to approximately 32.3 months). Brief summary: The purpose of this multicenter study in China is to evaluate the safety and efficacy of tiragolumab plus atezolizumab and carboplatin and etoposide (CE) compared with placebo plus atezolizumab and CE in participants with untreated extensive-stage small cell lung cancer.