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Life sciences · Journal article
Siberian Journal of Oncology · September 21, 2026
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The aim of the study was to improve treatment efficacy for patients with locally advanced nasal cavity and paranasal sinus cancer using intraoperative spectroscopy (IS) and photodynamic therapy (PDT). Material and Methods. To improve immediate and long-term treatment outcomes of combined modality of locally advanced nasal cavity and paranasal sinus cancer. The study included 80 patients with locally advanced nasal cavity and paranasal sinus cancer, who were treated from 2011 to 2024. The patients were divided into two groups: the study group (n=40) and the control group (n=40). Patients in both groups received preoperative radiation therapy at a total dose of 44 Gy followed by surgery. The study group also underwent spectroscopic wound examination and photodynamic therapy during surgery. Results. The five-year relapse-free survival and overall survival rates was significantly higher in the study group (46.0 % and 47 %, respectively) than in the control group (15.0 % and 37.5 %, respectively). Conclusion. The use of intraoperative spectroscopy in combination with photodynamic therapy increase the five-year relapse-free and overall survival rates of patients with locally advanced nasal cavity and paranasal sinus cancer. Photodynamic therapy accelerates wound healing, promotes implant and transplant integration in the recipient zone, and reduces the risk of tumor recurrence.