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Biological Research and Disease Studies / Viral Infections and Outbreaks Research / Mosquito Borne Diseases and Control · Journal article
International Journal for Multidisciplinary Research · August 16, 2026
Encouraging direction, but not yet definitive.
This single-centre, cross-sectional study of 67 RT-PCR-confirmed dengue patients found DENV-2 predominance (46.3%) and a significant association between serotype and disease severity (p=0.012), with platelet count decline from 142,800/µL in uncomplicated dengue to 42,300/µL in severe dengue (p<0.001). The results suggest DENV-2 and thrombocytopenia as potential severity markers but require prospective validation and replication in other settings.
Hospital-based cross-sectional analytical study. Clinically suspected dengue patients attending Index Medical College Hospital and Research Centre, Indore, India; enrollment period January 2023 to January 2026.. Intervention: Dengue virus serotyping by real-time RT-PCR (DENV-1, DENV-2, DENV-3, DENV-4). Compared with: Disease severity classification (dengue without warning signs, dengue with warning signs, severe dengue). n = 67. Index Medical College Hospital and Research Centre, Indore, India.
Real-time RT-PCR confirmed dengue in 67 of 290 (23.1%) clinically suspected patients DENV-2 was predominant at 46.3%, followed by DENV-3 (26.9%), DENV-1 (20.9%), DENV-4 (3.0%), and mixed infections (3.0%) Serotype significantly associated with disease severity, p=0.012
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The association of DENV-2 with severe dengue and the steep platelet count decline suggest potential utility for early risk stratification; however, the single-centre design and lack of prospective follow-up limit immediate clinical application. Replication in larger, multicentre cohorts and adjustment for confounders would be needed before integrating serotype-based risk prediction into clinical practice.
A single-centre cross-sectional study with confirmed dengue cases and RT-PCR serotyping showing associations between DENV-2 and disease severity, supported by hematological markers, but lacking prospective design and external validation.
As stated by the source record.
Quoted from the source exactly as published.
The association of DENV-2 with severe dengue and the steep platelet count decline suggest potential utility for early risk stratification; however, the single-centre design and lack of prospective follow-up limit immediate clinical application. Replication in larger, multicentre cohorts and adjustment for confounders would be needed before integrating serotype-based risk prediction into clinical practice.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
Abstract Background: Dengue disease severity varies by viral serotype and host factors. This study examined associations between dengue virus (DENV) serotypes, disease severity, and clinical-hematological parameters. Aims & Objectives: To investigate the molecular epidemiology of circulating dengue serotypes, identify DENV-1 to DENV-4 by RT-PCR, determine their demographic and clinical distribution, assess associations with disease severity, and generate data to strengthen dengue surveillance and public health interventions. Methods: A hospital-based cross-sectional analytical study was conducted among 290 clinically suspected dengue patients at Index Medical College Hospital and Research Centre, Indore, from January 2023 to January 2026. Serum samples were screened using the SD BIOLINE™ Dengue Duo Rapid Test, followed by viral RNA extraction and real-time RT-PCR with the RealStar® Dengue Type RT-PCR Kit 1.0. Dengue serotypes were identified, and clinical and hematological parameters were compared according to disease severity. Results: Real-time RT-PCR confirmed dengue infection in 67 (23.1%) patients. DENV-2 was the predominant serotype (46.3%), followed by DENV-3 (26.9%), DENV-1 (20.9%), DENV-4 (3.0%), and mixed infections (3.0%). Serotype was significantly associated with disease severity (p=0.012). Mean platelet count declined significantly from 142,800/µL in dengue without warning signs to 42,300/µL in severe dengue (p<0.001). Thrombocytopenia was the most common hematological abnormality (88.1%). DENV-2 infection, platelet count <50,000/µL, bleeding manifestations, and abdominal pain were independently associated with severe dengue. Conclusion: DENV-2 predominated and was significantly associated with severe dengue. Molecular serotyping combined with clinical and hematological assessment may facilitate early identification of patients at risk of severe disease.
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