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Life sciences · Observational Study
ClinicalTrials.gov · September 22, 2026
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Observational Study.
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Registry record from ClinicalTrials.gov (NCT07832903). This is a study registration, not published results. Lead sponsor: Assiut University. Recruitment status: NOT_YET_RECRUITING. Study type: OBSERVATIONAL. Enrollment: 120 participants (ESTIMATED). Conditions: Sepsis. Interventions: DIAGNOSTIC_TEST: Serial Complete Blood Counts (CBC). Primary outcome measures: In-hospital mortality , From hospital admission until hospital discharge, assessed up to 28 days.. Brief summary: This observational study aims to determine if tracking changes in blood platelets over time can help predict the clinical outcomes of adult patients hospitalized with sepsis. While current medical scoring systems (like SOFA and APACHE) help doctors evaluate a patient's risk when they are first admitted, they are often static and may not capture how the body's response changes during the infection. Platelet count and the size of the platelets (mean platelet volume) change dynamically during sepsis. Researchers will observe the routine daily blood test results of adult sepsis patients during their first 7 to 14 days in the hospital to track these changes. By calculating specific platelet ratios and analyzing their trajectories, the study hopes to find out if these simple, cost-effective markers can accurately predict a patient's risk of in-hospital mortality, and if they can improve the accuracy of current standard severity scores.