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Life sciences · Preprint
arXiv · August 10, 2026
The material analysed did not support any firm read.
This is a computer science preprint describing CPDA, a machine-learning algorithm for unsupervised time-series domain adaptation in non-clinical data. It presents no clinical data, health outcomes, patient cohorts, or evidence relevant to clinical decision-making.
Preprint.
CPDA is proposed to align source and target class-conditional latent path distributions using a composite signature-spectral kernel Method tested on 13 time-series domain adaptation benchmarks against 30 discrepancy, adversarial, and pseudo-labeling baselines Theoretical analysis provided showing CPDA defines a valid kernel discrepancy and yields class-conditional target-risk bound
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This is a machine-learning methods paper without clinical outcomes, patient data, or health-related validation; it does not address a question a clinician or clinical researcher would use PeerCurrent to answer.
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Unsupervised time-series domain adaptation (DA) addresses the challenge of transferring a classifier from a labeled source domain to an unlabeled target domain under distribution shifts induced by different users, sensors, devices, acquisition conditions, or temporal dynamics. Existing methods typically mitigate this shift by aligning marginal feature distributions through adversarial training, optimal transport, or moment-based discrepancies. In this paper, we propose Class-Conditional Path Distribution Alignment (CPDA), a non-adversarial discrepancy-based framework that aligns source and target class-conditional latent path distributions rather than only global feature marginals. CPDA introduces a composite signature-spectral kernel that jointly captures pooled semantic features, temporal path structure, frequency-domain information, and low-rank path-signature dynamics, while using source labels and target soft pseudo-labels to perform class-preserving alignment. We further provide a theoretical analysis showing that CPDA defines a valid kernel discrepancy, admits existing moment-matching methods as restricted cases, and yields a class-conditional target-risk bound. Extensive experiments with CNN, ResNet18, and TCN backbones on 13 different time-series DA benchmarks demonstrate the effectiveness of CPDA against 30 discrepancy, adversarial, and pseudo-labeling baselines.
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