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Nosocomial Infections in ICU · Journal article
Astrakhan Medical Journal · August 5, 2026
Early or partial results. Treat as a signal, not a conclusion.
This is a single-centre descriptive survey documenting antibiotic resistance in E. coli and K. pneumoniae isolates recovered from neonatal samples in Volgograd. The study reports 100% resistance to multiple antibiotic classes but does not quantify the number of isolates tested, clinical outcomes, or compare findings to other settings.
Single-centre descriptive cross-sectional survey. Newborns aged 4 days to 4 months admitted to neonatal ICU at Family Medicine clinic in Volgograd.. Intervention: Bacteriological culture and susceptibility testing of clinical specimens.. Family Medicine clinic, Volgograd, Russia..
K. pneumoniae showed 100% resistance to beta-lactams (cephalosporins, cefepime, ceftriaxone), aminoglycosides (gentamicin, amikacin), fluoroquinolones (ciprofloxacin, levofloxacin), and some carbapenems (ertapenem) E. coli demonstrated 100% resistance to second-generation cephalosporins (cefazolin, cefuroxime), aminoglycosides (gentamicin, amikacin), fluoroquinolones (ciprofloxacin, levofloxacin), and carbapenems (ertapenem)
Clinical outcomes, infection rates, or patient mortality not assessed.
The findings highlight severe antibiotic resistance in common neonatal pathogens in this setting, but without total isolate counts or clinical correlates, clinicians cannot determine prevalence, generalisability, or treatment implications.
Single-centre descriptive survey of antibiotic resistance patterns in neonatal samples; no comparator, no hypothesis test, and no sample size justification reported.
As stated by the source record.
Quoted from the source exactly as published.
The findings highlight severe antibiotic resistance in common neonatal pathogens in this setting, but without total isolate counts or clinical correlates, clinicians cannot determine prevalence, generalisability, or treatment implications.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
Antibiotic resistance is one of the most serious threats to global health in the modern world. In the context of all these events, the growing number of infectious diseases caused by polyresistant strains of microorganisms in neonatology departments is of particular concern. Escherichia coli and Klebsiella pneumoniae belong to the “ESKAPE” group of pathogens. This group is included in the priority list in the fight against their growing resistance, since “ESKAPE” pathogens are most often found as the causative agent of healthcare-associated infections and in neonatal intensive care units. Goal. Assessment of antibiotic resistance of E. coli and K. pneumoniae microorganisms in neonatal intensive care units in Volgograd. Materials and methods. The work was carried out in the clinic of “Family Medicine” in Volgograd. The material for the study was smears from the pharynx, feces, blood, urine of newborns from 4 days to 4 months. Identification of microorganisms and determination of the sensitivity of bacteria to antimicrobial drugs were performed using a bacteriological automatic analyzer. Results. As a result of the study, it was found that K. pneumoniae exhibits absolute resistance (100 %) to most common classes of antibiotics, including beta-lactams (for example, cephalosporins of the first generation, cefepime, ceftriaxone), aminoglycosides (gentamicin, amikacin), fluoroquinolones (ciprofloxacin, levofloxacin) and even some carbapenems (ertapenem). E. coli showed complete resistance (100 %) to a number of important groups of antibiotics, including second-generation cephalosporins (cefazolin, cefuroxime), aminoglycosides (gentamicin, amikacin), fluoroquinolones (ciprofloxacin, levofloxacin) and carbapenems (ertapenem). Conclusion. The vast majority of K. pneumoniae strains are absolutely resistant to a number of broad-spectrum antibiotics, including penicillins, cephalosporins, aminoglycosides, and fluoroquinones. Moreover, despite the relatively lower excretion of E. coli, this microorganism is also characterized by a high level of resistance to key antibiotics.
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