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Stomach Cancer / Stomach Neoplasms / Gastric Adenocarcinoma and Proximal Polyposis of the Stomach (GAPPS) · Observational Study
ClinicalTrials.gov · August 18, 2026
Early or partial results. Treat as a signal, not a conclusion.
This is a completed observational registry study of 733 participants with hereditary gastric cancer syndromes or predisposition. The study collected clinical, pathologic, and genomic data over 10 years to characterize natural history; however, no results are reported in this registry record, so no clinical findings or effect estimates can be evaluated.
Observational. Stomach Neoplasms, Stomach Cancer, Gastric Adenocarcinoma and Proximal Polyposis of the Stomach (GAPPS), Hereditary Diffuse Gastric Cancer (HDGC), Familial Dif…; age from 2 Years; accepts healthy volunteers. Intervention: Cohort 1. n = 733. 1 site: United States.
This is a completed observational registry study of 733 participants with hereditary gastric cancer syndromes or predisposition. The study collected clinical, pathologic, and genomic data over 10 years to characterize natural history; however, no results are reported in this registry record, so no clinical findings or effect estimates can be evaluated.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
No clinical impact can be assessed from this registry record, as results have not been reported. Clinicians should await publication of outcomes from this completed cohort to understand the natural history and genomic landscape of hereditary gastric cancer syndromes.
This is a completed observational registry study with no published results reported; it characterizes natural history and collects genomic data on hereditary gastric cancer syndromes but does not test an intervention or report clinical outcomes.
As stated by the source record.
Quoted from the source exactly as published.
No clinical impact can be assessed from this registry record, as results have not been reported. Clinicians should await publication of outcomes from this completed cohort to understand the natural history and genomic landscape of hereditary gastric cancer syndromes.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
What is missing. This record has no key findings. That is a gap in the analysis, not a judgement about the study.
Registry record from ClinicalTrials.gov (NCT03030404). This is a study registration, not published results. Lead sponsor: National Cancer Institute (NCI). Recruitment status: COMPLETED. Study type: OBSERVATIONAL. Enrollment: 733 participants (ACTUAL). Conditions: Stomach Neoplasms, Stomach Cancer, Gastric Adenocarcinoma and Proximal Polyposis of the Stomach (GAPPS), Hereditary Diffuse Gastric Cancer (HDGC), Familial Diffuse Gastric Cancer. Primary outcome measures: Characterization of the natural and clinical histories of hereditary gastric cancer syndromes , 10 years. Brief summary: Background: Gastric cancers are cancers of the stomach. Hereditary ones are passed from parent to child. Researchers want to gather data about hereditary gastric cancers. They want to learn about changes these cause in the body and about the genes involved. Objective: -To gather data about hereditary gastric cancer. Eligibility: * People at least 2 years old with personal or family history with a hereditary gastric cancer. * People at least 2 years old with gene changes that lead to such cancer or a lesion that may be hereditary. Design: * Participants will be screened in a separate protocol. * Participants will have: * Physical exam * Medical history * Blood tests * Scans * Photos of skin lesions and other findings * Gynecology consultation for women * Cheek swab (some participants) * For some participants, their relatives will be asked to join the study. * Some participants will be asked to allow the study to get stored tissue samples for relatives who have died. * Some samples will be sent to outside labs. All personal data will be protected. Samples will be destroyed when the study ends. * Participants will get the results of genetic testing. * Participants who cannot come to the NIH clinic may just give a cheek swab and have genetic testing done. * Some participants will be contacted for more testing.
Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.