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Life sciences · Phase 4 Trial
ClinicalTrials.gov · September 14, 2026
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Phase 4 Trial.
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Registry record from ClinicalTrials.gov (NCT04296565). This is a study registration, not published results. Lead sponsor: VA Office of Research and Development. Recruitment status: COMPLETED. Phase: PHASE4. Study type: INTERVENTIONAL. Enrollment: 121 participants (ACTUAL). Conditions: Mild Cognitive Impairment. Interventions: BEHAVIORAL: Usual Care; BEHAVIORAL: WATER+CT. Primary outcome measures: Cognitive Function Composite Score (ADAS-Cog-Exe) , 8 months. Brief summary: This four-year study will evaluate the efficacy of an exercise training augmentation for cognitive training intervention to improve memory performance in Veterans with a diagnosis of amnestic Mild Cognitive Impairment (aMCI). This is a two-phased trial: 1) an exercise phase and 2) a cognitive training program. The exercise phase will be an aquatic based exercise program. A combination of exercise and cognitive training programs designed for persons without cognitive impairment have significantly improved memory more than other single intervention groups (exercise only, cognitive training only) and given the success of combination training programs with healthy older adults, it is important to adapt these programs for persons beginning to exhibit clinically significant memory problems, such as those with aMCI.