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Life sciences · Journal article
Journal of Skin and Sexually Transmitted Diseases · November 2, 2026
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Journal article.
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Topical immunomodulators play a versatile and essential role in managing various skin disorders. Topical immunomodulators are a class of medications applied directly to the skin that modify or regulate local immune responses. Unlike systemic immunosuppressants or stimulants, these agents act locally, offering a targeted therapy approach with enhanced safety. Topical immunomodulators work by modulating immune cell activity, cytokine production, or intracellular signaling pathways involved in inflammation and immune dysregulation. They are widely used in dermatology to treat inflammatory, autoimmune, infectious, and neoplastic skin conditions by either suppressing overactive immune responses (e.g., in atopic dermatitis) or stimulating immune activity (e.g., in viral warts or skin cancers).