Life sciences · Interventional Study
ClinicalTrials.gov · November 9, 2026
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Interventional Study.
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Registry record from ClinicalTrials.gov (NCT07924917). This is a study registration, not published results. Lead sponsor: Tianjin Medical University General Hospital. Recruitment status: RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 75 participants (ESTIMATED). Conditions: Major Depressive Disorder (MDD). Interventions: DEVICE: Single-target active temporally interfering electrical stimulation; DEVICE: Dual-target active temporally interfering electrical stimulation; DEVICE: Sham temporally interfering electrical stimulation. Primary outcome measures: Hamilton Depression Rating Scale 17-item (HAMD-17) , Baseline, Week 1, Week 2, Week 4.. Brief summary: Temporally interfering (TI) electrical stimulation is a novel noninvasive neuromodulation technique with high spatial resolution. Although its effects on human brain function and behavior have been increasingly investigated, its clinical utility in major depressive disorder (MDD) has not been established. This trial aims to evaluate the efficacy and safety of TI electrical stimulation in MDD patients.