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Cancer Research and Treatment / Gestational Diabetes Research and Management · Journal article
Borneo Nursing Journal · August 10, 2026
Early or partial results. Treat as a signal, not a conclusion.
This small retrospective case-control study found that gestational diabetes mellitus history and neonatal hypothermia were significantly associated with hypoglycemia in neonates, while maternal obesity and advanced maternal age were not. The findings are hypothesis-generating but lack adjustment for confounders and generalizability beyond a single centre.
Retrospective case-control study. Neonates at Aura Syifa Hospital with assessment of maternal factors (obesity, gestational diabetes mellitus history, age ≥35 years) and neonatal hypothermia status.. n = 36. Aura Syifa Hospital (location not specified).
History of gestational diabetes mellitus significantly associated with neonatal blood glucose levels (p = 0.001; OR = 21.250) Neonatal hypothermia significantly associated with blood glucose levels (p = 0.000; OR = 4.600) Maternal obesity showed no significant relationship (p = 0.310; OR = 2.000)
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Findings suggest that screening for gestational diabetes mellitus and preventing hypothermia may be important for neonatal hypoglycemia risk identification, but the small size and single-centre design mean these associations require confirmation in larger cohorts before clinical implementation.
Small case-control study (n=36) with significant findings for two factors but no control for confounding and retrospective design limits causal inference.
As stated by the source record.
Quoted from the source exactly as published.
Findings suggest that screening for gestational diabetes mellitus and preventing hypothermia may be important for neonatal hypoglycemia risk identification, but the small size and single-centre design mean these associations require confirmation in larger cohorts before clinical implementation.
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In the neonatal period, hypoglycemia is the most common metabolic disorder that carries a risk of long-term neurological impairment. The purpose of this study was to analyze factors associated with blood glucose levels in neonates at Aura Syifa Hospital, including maternal obesity, history of gestational diabetes mellitus, maternal age ≥35 years, and neonatal hypothermia. This study was an observational analytic study with a retrospective case-control design using 36 respondents (18 cases, 18 controls) through purposive sampling technique. Univariate analysis and bivariate analysis with Chi-Square and Fisher's Exact Test were applied. Maternal obesity was found in the majority of respondents at 58.3%, hypothermia was experienced by most neonates at 63.9%, and blood glucose distribution showed equal proportions of hypoglycemia and normal at 50% each. Based on the statistical test results, there was no significant relationship between maternal obesity (p = 0.310; OR = 2.000) and maternal age ≥35 years (p = 0.298; OR = 0.481) with neonatal blood glucose levels. There was a significant relationship between history of gestational diabetes mellitus (p = 0.001; OR = 21.250) and hypothermia (p = 0.000; OR = 4.600) with neonatal blood glucose levels. Mothers who experienced gestational diabetes mellitus during pregnancy is the most dominant factor associated with neonatal blood glucose levels, followed by hypothermia. It is expected that healthcare providers will optimize blood glucose screening in neonates born to at-risk mothers and consistently implement hypothermia prevention measures from the time of delivery
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