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Life sciences · Preprint
arXiv · October 22, 2026
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In real-world applications, being able to explain why a prediction is made is often as important - if not more so - than achieving high accuracy. However, existing methods for sequential event prediction typically prioritize accuracy at the expense of interpretability. Neuro-symbolic approaches offer a promising direction to improve interpretability by learning symbolic rules, but extending them to next-event prediction is challenging due to the presence of temporal dependencies. We introduce RULES, a neuro-symbolic model that learns sequential rules directly from data, and combine it with a residual network to form RUNES (Rule Network for Event Sequences). RULES accurately recovers ground truth rules from synthetic data and discovers compact, interpretable rule sets on real data. RUNES combines these rules additively with a residual network, achieving competitive accuracy while providing transparent access to active rules and how residuals adjust predictions.