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Life sciences · Interventional Study
ClinicalTrials.gov · October 14, 2026
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Interventional Study.
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Registry record from ClinicalTrials.gov (NCT07873060). This is a study registration, not published results. Lead sponsor: Qilu Hospital of Shandong University. Recruitment status: RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 80 participants (ESTIMATED). Conditions: Depressive Disorder, Major Depressive Disorder, Adolescence. Interventions: DEVICE: 10 Hz Repetitive Transcranial Magnetic; DEVICE: Intermittent Theta Burst Stimulation. Primary outcome measures: Change in Hamilton Depression Rating Scale-24 (HAMD-24) Total Score , Baseline, Week 2, and Week 6. Brief summary: This trial compares two transcranial magnetic stimulation (TMS) protocols-10 Hz rTMS and intermittent theta burst stimulation (iTBS)-in adolescents with major depressive disorder. Eighty participants aged 11-19 years will be randomly assigned to receive either 10 Hz rTMS or iTBS over a two-week period. Clinical symptoms, cognitive function, brain imaging, and neurophysiological measures will be assessed at baseline, immediately post-treatment, and at a 1-month follow-up to evaluate both the immediate and sustained therapeutic effects and underlying mechanisms.