Loading
Life sciences · Journal article
Annals of Medicine · October 14, 2026
No summary has been generated for this record yet. What follows is drawn from its source metadata only.
Journal article.
No findings were extractable from the material analysed.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
The source did not state who this applies to in practice.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
This record has not been graded across any dimension yet. Treat the label above as provisional and read the source.
What is missing. This record has no bottom line, key findings, reported figures, evidence dimensions. That is a gap in the analysis, not a judgement about the study.
Background. Infertility and its treatment impose significant psychosocial burdens that impair quality of life (QoL). Its impact on pregnancy outcomes after embryo transfer (ET) in assisted reproduction technologies (ART) remains underexplored.Objective. This study prospectively examined the association between QoL-measured by the FertiQoL instrument-and cumulative live birth rates (CLBRs) in women undergoing ART.Methods. In this prospective cohort study, 1,233 women initiating IVF/ICSI completed the FertiQoL questionnaire pretreatment. Latent profile analysis (LPA) identified distinct QoL subgroups based on domain scores. Multivariable regression models, adjusted for confounders, assessed associations between QoL profiles/scores and pregnancy outcomes, with CLBRs as the primary endpoint. Smoothed curve fitting and threshold analyses explored nonlinear relationships.Results. LPA delineated three FertiQoL subgroups: Low (n = 278), Medium (n = 676), and High (n = 279). Multivariate regression revealed that, relative to the Low-QoL group, the Medium-QoL group had significantly higher CLBRs (adjusted odds ratio [OR]: 1.704; 95% CI: 1.217-2.380) and reduced miscarriage risk (adjusted OR: 0.513; 95% CI: 0.304-0.875). Smoothed curve fitting indicated a nonlinear association between total FertiQoL score and CLBRs. Threshold analysis identified a cutoff of 74.306 (log-likelihood ratio test p = 0.054); below this value, each one-unit increase in score corresponded to a 2.1% higher CLBR (adjusted OR: 1.021; 95% CI: 1.006-1.036). Bootstrap internal validation confirmed the stability of this cutoff.Conclusion. QoL was significantly associated with CLBRs following ET. A threshold effect was evident: improvements in QoL below a score of 74.306 were associated with higher live birth rates. These findings underscore the importance of integrating QoL assessment and intervention into infertility care.