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Life sciences · Preprint
arXiv · October 14, 2026
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Single-channel radio-frequency (RF) signal separation is important for interference mitigation when a signal of interest overlaps with a co-channel interferer in time and frequency. Classical matched filtering and LMMSE receivers are limited under structured non-Gaussian interference, while diffusion and score-based methods often require iterative sampling or optimization. We propose FlowSep-RF, a rectified flow matching framework that learns a clean-endpoint transport from the received mixture to the signal of interest. The model combines time-domain IQ samples with frequency-domain features and recovers the separated waveform using one endpoint velocity evaluation. We evaluate FlowSep-RF on QPSK mixtures with OFDM-BPSK, OFDM-QPSK, and RFChallenge CommSignal2 interference against classical, discriminative, and generative baselines. FlowSep-RF achieves the lowest average BER and MSE among evaluated baselines across all three settings with one-step inference.