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Life sciences · Interventional Study
ClinicalTrials.gov · September 22, 2026
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Interventional Study.
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Registry record from ClinicalTrials.gov (NCT07390981). This is a study registration, not published results. Lead sponsor: First People's Hospital of Hangzhou. Recruitment status: NOT_YET_RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 114 participants (ESTIMATED). Conditions: Major Depressive Disorder. Interventions: DRUG: Selective Serotonin Reuptake Inhibitors (SSRIs); PROCEDURE: Sham Intradermal Acupuncture; PROCEDURE: Intradermal Acupuncture. Primary outcome measures: SSRI Dose Reduction Rate , Week 4, Week 8 (end of treatment), Week 12 (follow-up). Brief summary: This randomized controlled trial aims to evaluate the clinical efficacy of intradermal acupuncture as an adjunctive intervention to assist selective serotonin reuptake inhibitor (SSRI) dose reduction or discontinuation in adult patients with major depressive disorder (MDD). Participants receiving SSRIs and planning gradual dose reduction or discontinuation will be randomly assigned to one of three groups: SSRI tapering alone, sham intradermal acupuncture plus SSRI tapering, or intradermal acupuncture plus SSRI tapering. Clinical outcomes and autonomic nervous system function will be assessed to determine the effectiveness and potential mechanisms of intradermal acupuncture in facilitating SSRI reduction and alleviating withdrawal-related symptoms.