Life sciences · Preprint
arXiv · September 8, 2026
Posted before peer review. The findings may change or fail to hold.
This is a theoretical mathematics and computer science preprint on polynomial-time sampling algorithms for Ising models and Bayesian sparse linear regression, not a clinical study. It has not undergone peer review and contains no empirical data, patient outcomes, or evidence relevant to clinical practice.
Preprint.
Polynomial-time sampler for fixed-magnetization Sherrington–Kirkpatrick model at any inverse temperature β > 0 under arbitrary external fields, when k ≤ c_β d Improved measurement complexity for Bayesian sparse linear regression from n ≳ k³ log³ d to n ≳ k^(3/2) log² d + k log³ d
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
The source did not state who this applies to in practice.
This is a theoretical computer science preprint on arXiv presenting novel algorithmic frameworks for sampling problems; it has not been peer reviewed and contains no empirical validation or clinical data.
Quoted from the source exactly as published.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
Sparsity is a powerful structural resource in optimization and statistics. We develop frameworks for leveraging sparsity in sampling problems over the Hamming slice $\mathcal{X}_k^d:=\{\mathbf{x}\in\{\pm 1\}^d:|\{i:\mathbf{x}_i=1\}|=k\}$, in high-dimensional regimes where $k\ll d$ (i.e., where $\mathcal{X}_k^d$ is \emph{highly magnetized}). We use our frameworks to design improved samplers for canonical problems in the study of \emph{Ising models} and \emph{Bayesian sparse linear regression}. Our first main result considers the \emph{Sherrington--Kirkpatrick} (SK) model restricted to fixed-magnetization slices $\mathcal{X}_k^d$. We give a polynomial-time sampler for fixed-magnetization SK models at any inverse temperature $β>0$, under arbitrary external fields, provided that $k\le c_βd$ for an appropriate constant $c_β$. By combining this result with an annealing strategy for estimating normalizing constants, we obtain polynomial-time samplers for the SK model at arbitrarily low temperatures under a sufficiently strong external field of strength $h$. In the large-$β$ limit, our framework permits sampling at field strengths within constant factors of the \emph{Almeida--Thouless line} delineating the replica-symmetric and replica-symmetry-breaking regions ([dAT78]), improving polynomially over the field strength $h(β)$ required by the recent work of [BAR26]. Our second main result concerns the measurement complexity of polynomial-time Bayesian sparse linear regression. Recent work by [KSTZ25] shows how to sample from the canonical \emph{Gaussian spike-and-slab posterior} with expected sparsity $k$, at any signal-to-noise ratio, given $n\gtrsim k^3\log^3 d$ Gaussian measurements. We improve this requirement to $n\gtrsim k^{3/2}\log^2 d+k\log^3 d$, using a common sparsity-aware framework underlying both our results.
Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.