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Life sciences · Interventional Study
ClinicalTrials.gov · September 18, 2026
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Interventional Study.
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Registry record from ClinicalTrials.gov (NCT06650995). This is a study registration, not published results. Lead sponsor: Technical University of Munich. Recruitment status: RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 40 participants (ESTIMATED). Conditions: HFpEF - Heart Failure With Preserved Ejection Fraction, Atrial Fibrillation. Interventions: OTHER: Exercise training. Primary outcome measures: Delta of peak oxygen consumption , 14 weeks. Brief summary: The investigators analyze the impact of exercise and ablation in patients with symptomatic short-persistent atrial fibrillation (Afib) and heart failure with preserved ejection fraction (HFpEF). It is hypothesized that the combination of ablation and exercise better improves peak oxygen consumption (VO2peak) through improvement of peripheral (exercise training) and central (ablation) adaptations. Exercise intervention will contain a 12-week combined, video-based, supervised, endurance, resistance and respiratory training.