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Life sciences · Journal article
Biomacromolecules · September 8, 2026
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This is a narrative review of radical polymerization strategies and their application to cellular engineering, drug delivery, and cancer therapy. It synthesizes technical principles and recent innovations but presents no original empirical data, clinical outcomes, or quantitative results.
Narrative review.
Review covers evolution from non-degradable to biodegradable to smart responsive polymer systems in biomedical contexts. Strategies classified include thermal decomposition, photoinitiation, environment-triggered polymerization, ATRP, and RAFT. Applications highlighted: cell surface engineering, intracellular imaging, drug delivery, and cancer therapy.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
The source did not state who this applies to in practice.
This is a narrative review summarizing technical strategies and applications of radical polymerization in cellular settings; it presents no empirical data, clinical outcomes, or original experimental results.
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Abstract This review summarizes recent progress and applications of radical polymerization within cellular microenvironment. It starts with the evolution of synthetic polymers in biomedical applications, from early non-degradable and biodegradable materials to advanced smart responsive systems. The fundamental principles of radical polymerization are introduced, followed by a systematic classification of strategies employed in cellular settings, including thermal decomposition initiation, photoinitiation, intracellular environment-triggered polymerization, and controlled radical polymerization techniques such as atom transfer radical polymerization (ATRP) and reversible addition−fragmentation chain transfer polymerization (RAFT). This article highlights key innovations in cell surface engineering, intracellular imaging, drug delivery, and cancer therapy, with an emphasis on strategies that leverage cellular metabolism or disease-specific microenvironments for endogenous polymerization initiation. Current challenges, including spatiotemporal control, biocompatibility, and oxygen tolerance, are critically discussed, along with potential solutions. Finally, future perspectives on the application of radical polymerization in tissue engineering, immunomodulation, and precision medicine are presented.
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