Loading
Life sciences · Journal article
Acs Applied Nano Materials · September 23, 2026
No summary has been generated for this record yet. What follows is drawn from its source metadata only.
Journal article.
No findings were extractable from the material analysed.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
The source did not state who this applies to in practice.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
This record has not been graded across any dimension yet. Treat the label above as provisional and read the source.
What is missing. This record has no bottom line, key findings, reported figures, evidence dimensions. That is a gap in the analysis, not a judgement about the study.
Abstract Carbon monoxide (CO), as a glycolysis inhibitor, can reverse tumor resistance to therapy. However, uncontrolled release and the inadequacy of monotherapy often compromise therapeutic outcomes. Herein, we developed nanoplatforms (FCBON NPs) based on the photosensitizer (BON) and CO-delivering polymer (DSPE-PEG (FeCO)) to achieve synergistic photodynamic/photothermal/gas therapy (PDT/PTT/GT). FCBON NPs enable controlled CO release through a dual-responsive cascade mechanism including the activation by overexpressed hydrogen peroxide in the tumor and reactive oxygen species (ROS) generated during BON-mediated PDT. The released CO effectively inhibits glycolysis via GLUT1 suppression, leading to adenosine triphosphate (ATP) depletion and heat shock proteins (HSP70) downregulation, which sensitizes tumors to mild-temperature photothermal therapy (MTPTT) by attenuating their thermal resistance. In vitro and in vivo therapeutic results demonstrated that the synergistic PDT/PTT/GT achieves potent therapeutic effects compared to monotherapy. By demonstrating the power of CO-mediated metabolic intervention, this study provides a valuable framework for designing controlled gas-releasing nanoplatforms for enhanced multimodal cancer therapy.