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Life sciences · Interventional Study
ClinicalTrials.gov · October 7, 2026
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Interventional Study.
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Registry record from ClinicalTrials.gov (NCT07862205). This is a study registration, not published results. Lead sponsor: Mayo Clinic. Recruitment status: NOT_YET_RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 60 participants (ESTIMATED). Conditions: Major Depressive Disorder (MDD), Treatment Resistant Depression, Major Depression. Interventions: DEVICE: MagVenture TMS Therapy System with Localite Navigation System and actiCHamp EEG. Primary outcome measures: Feasibility of closed-loop EEG guided iTBS in adult participants with MDD. , 6 weeks and 12 weeks post-treatment. Brief summary: The purpose of this research is to see if an experimental treatment for depression called intermittent theta burst stimulation (iTBS), a form of transcranial magnetic stimulation (TMS) can be improved for better results using electroencephalography (EEG) recordings (brain waves) for individuals with Major Depressive Disorder (MDD). This is a feasibility study to test a "closed-loop" procedure which guides the timing of this FDA-cleared form of TMS. Each participant will receive an active experimental treatment, and the timing of the TMS pulses will be at one of three phases in the brain wave of interest.